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ProteomicsQuantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia
Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize ear...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042249 | Pride
Adult hematopoietic progenitor Tmtpro Mll-rearranged leukemia Fetal hematopoietic progenitor 
ProteomicsCo-immunopercipitation of YPEL4 protein in mouse hematopoietic cells
Co-immunopercipitation of YPEL4 protein in mouse hematopoietic cells
ORGANISM(S): Mus musculus (Mouse) 
2021-08-06 | PXD025242 | Pride
Ypel4 Mouse Erythropoiesis Hematopoiesis 
UnknownQuantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis.
Not available
S-EPMC9157258 | biostudies-literature
ProteomicsEGR1 regulation in human bone marrow stromal cells
Human bone marrow stromal cells (BMSCs) are key elements of the hematopoietic environment and they play a central role in bone and bone marrow physiology. However, how key BMSC functions are regulated is largely unknown. We analyzed the role of the immediate early response transcription factor EGR1 ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-27 | PXD011767 | Pride
Human Bone marrow Stromal cells 
ProteomicsQuantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.
We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD049014 | Pride
Bone marrow Leukemia Secretome Extracellular Fetal liver Data-independent acquisition Hematopoietic progenitors 
ProteomicsSecretome and phosphoproteome analysis of THP-1 and KOPN-8 cells treated with Insulin-like growth factor 2.
We describe the secretome and phosphoproteome of human leukemia cell lines, THP-1 and KOPN-8, treated with Insulin-like growth factor 2 (IGF2) using data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD049016 | Pride
Leukemia Secretome Extracellular Data-independent acquisition Phosphoproteome Igf2 
ProteomicsQuantitative extracellular proteome analysis of fetal liver and adult bone marrow
We describe the proteomic composition of the extracellular environment of fetal and adult hematopoietic progenitors by data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042251 | Pride
Tissue interstitial fluid Bone marrow Fetal liver Data-independent acquisition Extracellular 
UnknownYippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.
Not available
S-EPMC8342551 | biostudies-literature
ProteomicsQuantitative analysis of redox proteome reveals protein thiol switches regulating fundamental processes in developmental hematopoiesis
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behaviour in normal and malignant haematopoiesis. In this work, we have applied a quantitative mass spectrometry-based redox proteomic approa...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033115 | Pride
Oxidative modifications Oxidative stress Redox proteomics Hydrogen peroxide Human embryonic stem cells 
ProteomicsFoetal and adult HSPCs - Comprehensive Proteomic Characterization of Ontogenic Changes in Hematopoietic Stem and Progenitor Cells
Haematopoietic stem and progenitor cells (HSPCs) in the foetus and adult possess distinct molecular landscapes that regulate cell fate and change their susceptibility to initiation and progression of haematopoietic malignancies. The proteomic programs that govern these differences remain elusive. In...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-12 | PXD006876 | Pride
Haematopoiesis Mouse Adult bone marrow Foetal liver 
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