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TranscriptomicsProteasome regulator PSME4 reduces cellular inflammation and promotes an immunosuppressive tumor microenvironment
We observed that proteasome regulator PSME4 inhibits antigen presentation and reduces cellular inflammation in lung adenocarcinoma. As tumor inflammation and antigenicity are key to anti-tumor immunity, we examined the effect of PSME4 in vivo by injecting mice with either KP1.9 or KP1.9PSME4_KD lun...
ORGANISM(S): Mus musculus 
2023-03-04 | E-MTAB-10745 | biostudies-arrayexpress
ProteomicsNSCLC Lung Adenocarcinoma Proteomics
Alterations in cellular antigen processing and presenting machinery has gained increased interest as a hallmark of cancer-related inflammation. Growing evidence suggest that proteasome composition and immunoproteasome expression can influence the efficacy of cancer therapies. By applying proteasome ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD019573 | Pride
Mapp Proteasome Nsclc Degradome Lung cancer 
ProteomicsLung Adenocarcinoma (A549) Immunopeptidomics
Alterations in cellular antigen processing and presenting machinery has gained increased interest as a hallmark of cancer-related inflammation. Growing evidence suggest that proteasome composition and immunoproteasome expression can influence antigen processing. By performing immunopeptidomics on A5...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD028364 | Pride
A549 Nsclc Immunopeptidome Hla 
ProteomicsLung Adenocarcinoma (A549) Immunopeptidomics
Alterations in cellular antigen processing and presenting machinery has gained increased interest as a hallmark of cancer-related inflammation. Growing evidence suggest that proteasome composition and immunoproteasome expression can influence antigen processing. By performing immunopeptidomics on A5...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037365 | Pride
Immunopeptidomics Proteasome Nsclc 
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