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We demonstrate that miR-708 is one of the most highly overexpressed miRNAs in non-small cell lung cancer. High level of miR-708 in tumor is also associated with a reduced overall survival in lung adenocarcinomas from never smokers. Functionally, miR-708 overexpression increases the proliferation, m...
ORGANISM(S): Homo sapiens 
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression, playing significant roles in tissue development and disease progression. The antisense lncRNA Hnf1aos1 represents a particularly intriguing regulatory molecule in liver biology, functioning as a negative regulator ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD063297 | Pride
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
Approximately 15% of lung cancer cases are not associated with smoking and show molecular and clinical characteristics distinct from those in smokers. Epidermal growth factor receptor (EGFR) gene mutations, which are correlated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKIs), are mo...
ORGANISM(S): Homo sapiens 
Advantages of RNA-Seq over array based platforms are quantitative gene expression and discovery of expressed single nucleotide variants (eSNVs) and fusion transcripts from a single platform, but the sensitivity for each of these characteristics is unknown. We measured gene expression in a set of man...
ORGANISM(S): Homo sapiens 
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