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TranscriptomicsTranscription profiling of human hepatoma cell lines HepG2 and HepaRG using whole genome gene expression analysis before and after exposure to the GTX carcinogens AFB1 and BaP, and the NGTX carcinogens CsA, E2 and TCDD for 12 and 48 h
Direct comparison of the hepatoma cell lines HepG2 and HepaRG using whole genome gene expression analysis before and after exposure to the GTX carcinogens AFB1 and BaP and the NGTX carcinogens CsA, E2 and TCDD for 12 and 48 h.
ORGANISM(S): Homo sapiens 
2010-04-15 | E-MEXP-2458 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HepG2 cells treated with TCDD
The integration of different M-^SomicsM-^T technologies has already been shown in several in vivo studies to offer a complementary insight into cellular responses of toxic processes. We therefore hypothesize that the combining of transcriptomics and metabonomics data may improve the understanding of...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MEXP-2817 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary mouse hepatocytes reveals classification for genotoxic and non-genotoxic carcinogens by gene expression improves with exposure time
The prediction of possible carcinogenicity of chemicals for humans represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk at only limited reliability while simultaneously being expensive and long-lasting. In order to seek for alternatives, in the present study, the abil...
ORGANISM(S): Mus musculus 
2010-06-09 | E-MEXP-2209 | biostudies-arrayexpress
no omics definedTranscription profiling by array of mouse primary hepatocytes under treatment of genotoxic compounds.
Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds with addtional compounds
ORGANISM(S): Mus musculus 
2011-03-22 | E-MEXP-2636 | biostudies-arrayexpress
no omics definedTranscription profiling in primary mouse hepatocytes discriminates between true and false genotoxic compounds
Primary mouse hepatocytes are applied in this study as an in vitro system to discriminate false positive GTX compounds from true GTX compounds.
ORGANISM(S): Mus musculus 
2011-01-11 | E-MEXP-2539 | biostudies-arrayexpress
ModelsGall&Pin2022 - ODE model of the intestinal epithelium
We developed a compartmental model of the small intestinal epithelium that describes stem and progenitor cell proliferation and differentiation and cell migration onto the villus. The model includes a negative feedback loop from villus cells to regulate crypt proliferation and integrates heterogeneo...
2025-09-11 | MODEL2212120003 | BioModels
TransQST 
TranscriptomicsAnalysis of human healthy enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent Doxorubicin (DOX) sampled at four doses (1,10, 30 and 60uM) and three time points (24, 48 and 72h).
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11297 | biostudies-arrayexpress
TranscriptomicsAnalysis of human enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent 5-fluorouracil (5FU) in a dose-repeated exposure across three doses (10,100 and 1000uM) and sampled at three points (24, 48 and 72h) since initial exposure. Organoids were obtained from healthy human tissues.
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-9134 | biostudies-arrayexpress
TranscriptomicsWhole genome gene expression modifications associated with micronucleus formation in blood cells from nitrosamine-exposed humans
N-nitroso compounds (NOCs) can be formed through endogenous nitrosation in the human body and are known to induce micronuclei (MN) formation in vitro. Since lymphocytic MN represent a well-validated biomarker of effect with regard to carcinogenic risk in multiple target organs, establishing a link b...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23919 | biostudies-arrayexpress
TranscriptomicsLow dose human APAP exposure
Acetaminophen is the primary cause of acute liver toxicity in Europe/USA. Therefore, the FDA reconsiders recommendations concerning safe acetaminophen dosage/use. Current tests for liver toxicity are no ideal predictive markers for liver injury. Here, ‘omics techniques (global analysis of metabolomi...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-30418 | biostudies-arrayexpress
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