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ProteomicsHexameric VCP/p97 reprograms transcription by organizing enhancers with the ASPSCR1-TFE3 fusion oncoprotein
Aberrant transcription in alveolar soft part sarcoma (ASPS) is orchestrated by the fusion oncoprotein, ASPSCR1-TFE3, resulting from a gene fusion created by a t(X;17) chromosomal translocation. Proteomic analysis of co-immunoprecipitated ASPSCR1-TFE3 complexes revealed strong enrichment of VCP/p97, ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-11-23 | PXD022515 | Pride
Asps Ip-ms Tmt 
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-21 | PXD025067 | Pride
Yeast synthetic biology Monoterpene indole alkaloids Natural products 
ProteomicsProgrammable polyketide biosynthesis platform for production of aromatic compounds in yeast
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms are required. Here we present a novel yeast platform for bi...
ORGANISM(S): Saccharomyces Cerevisiae 
2020-02-11 | PXD013388 | panorama
UnknownUltrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.
Not available
S-EPMC7616143 | biostudies-literature
UnknownEvaluation of the Feasibility and Efficacy of Point-of-Care Antibody Tests for Biomarker-Guided Management of Coronavirus Disease 2019.
Not available
S-EPMC11911911 | biostudies-literature
UnknownZika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.
Not available
S-EPMC10775418 | biostudies-literature
ProteomicsA microbial supply chain for production of anti-cancer drug vinblastine
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to chemically synthesize, the world’s supply chain for vinblastine relie...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-09-09 | PXD024976 | panorama
UnknownPrevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease.
Not available
S-EPMC9990311 | biostudies-literature
UnknownRespiratory exacerbations are associated with muscle loss in current and former smokers.
Not available
S-EPMC8222105 | biostudies-literature
UnknownThe Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Not available
S-EPMC9447373 | biostudies-literature
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