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ProteomicsLung cancer and Normal Lung Tissue LC-MS/MS
The Chromosome-centric Human Proteome Project (C-HPP) was recently initiated as an international collaborative effort. Our team adopted chromosome 9 (Chr 9) and performed a bioinformatics and proteogenomic analysis to catalog Chr 9-encoded proteins from normal tissues, lung cancer cell lines and lun...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083969 | MassIVE
ProteomicsTop-down proteome of de-fatted Bos taurus milk from an animal with clinical mastitis
Quarter-milk samples were collected from a cow with clinical mastitis on day 13 and day 16 postpartum. Milk was collected from a clinical quarter with signs of abnormality (i.e., flakes, clots, blood) and one normal quarter of the same animal. Milk samples were processed with the MPLEx protocol (ht...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2022-02-09 | MSV000088805 | MassIVE
ProteomicsDeuterium-free, Three-plexed Peptide Di-Ethylation for Highly Accurate Quantitative Proteomics
The deuterium, frequently used stable isotope in isotopic labeling for quantitative proteomics, could deteriorate the accuracy and precision of proteome quantification owing to the retention time shift of deuterated peptides from the hydrogenated counterpart. Herein, we introduce a novel three-plexe...
ORGANISM(S): Homo sapiens (Human) 
2019-01-17 | PXD012117 | Pride
Isobaric labeling Quantitative accuracy Di-methylation Isotopic labeling Deuterium effect Di-ethylation 
ProteomicsIdentification of CDK1 phosphorylation of TFCP2L1 from murine embryonic stem cells and bladder cancer cells
Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orches...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-11-08 | PXD015635 | Pride
Pluripotency Cdk1 Stemness features Embryonic stem-cell Bladder cancer 
ProteomicsHDAC inhibition improves cardiopulmonary and mitochondrial function in a feline model with features of Heart Failure with Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFpEF) is a major global health problem but there are no effective therapies. The aim of this study was to assess the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian (feline) ...
ORGANISM(S): Felis catus (Cat) (Felis silvestris catus) 
2021-09-08 | PXD013663 | Pride
Myofibril relaxation Hypertrophy Cat Hdac Heart failure Acetylation proteomics Pulmonary hypertension Lung compliance 
Proteomicsanti-HA IP-MS of Pdzd8-3×HA knock-in mouse neocortex
Pdzd8-3xHA knock-in mice and control littermates at postnatal 10 days were put to sleep using medetomidine hydrochloride, midazolam and butorphanol. Pups were then put on the ice for 5 minutes and exsanguinated by terminal intracardial perfusion with ice-cold 2% paraformaldehyde in PBS. The neocorte...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-18 | PXD052134 | JPOST Repository
UnknownThe Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics.
Not available
S-EPMC5804835 | biostudies-literature
UnknownLong-Term Safety and Efficacy of Eculizumab in Aquaporin-4 IgG-Positive NMOSD.
Not available
S-EPMC8248139 | biostudies-literature
UnknownImpact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World.
Not available
S-EPMC8374310 | biostudies-literature
UnknownImpact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study.
Not available
S-EPMC9627847 | biostudies-literature
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