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MetabolomicsExplaining combinatorial effects of mycotoxins Deoxynivalenol and Zearalenone in mice with urinary metabolomic profiling
Urine metabolic profiling of mice was conducted utilizing gas chromatography-mass spectrometry (GC-MS) to investigate the combinatory effect of mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) on the metabolism of the mice. Experiments were conducted by means of five-week-old mice which were in...
2021-02-11 | MTBLS580 | MetaboLights
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
MetabolomicsEvaluation of significant features discovered from different data acquisition modes in mass spectrometry-based untargeted metabolomics

Despite the growing popularity of liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, no study has yet to systematically compare the performance of different data acquisition modes in the discovery of significantly altered metabolic features, which is an important task of untarget...

2020-10-02 | MTBLS1842 | MetaboLights
TranscriptomicsInvestigation of the gene expression pattern of human hepatocellular carcinoma (HCC) infiltrating M-NM-3M-NM-4T cells
Fresh human HCC tissue and paired pertumor liver tissue were acquired, isolation of the infiltrating lymphocytes was conducted by discontinous density gradient centrifugation in Percoll. After removal of dead cells and incubation with components of TCRM-NM-3/M-NM-4 isolation kit (Mitenyi Biotec), M-...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-38476 | biostudies-arrayexpress
UnknownThe WRKY Transcription Factor GmWRKY12 Confers Drought and Salt Tolerance in Soybean.
Not available
S-EPMC6320995 | biostudies-literature
TranscriptomicsSW1 mutant vs. Shewanella piezotolerans WP3 wild-type strain
The prophage and RF DNA of SW1 were removed from WP3 to construct the phage-free strain. The two strains were cultured at 4M-BM-0C and the transcriptional profiles were compared. WP3M-NM-^TSW1 is the test sample and WP3 wild-type is the reference sample. Three independent cultures were used for RNA ...
ORGANISM(S): Shewanella piezotolerans WP3 
2013-01-30 | E-GEOD-43882 | biostudies-arrayexpress
ProteomicsArabidopsis Hrd1 complex - PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex
We are using the immunoprecipitation coupled with mass spectrometry to identify additional components of the Arabidopsis Hrd1-containing ERAD complex
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-08-15 | PXD013400 | Pride
Erad Pawh2 Hrd1 Ebs7 Upr Er stress Pawh1 
MetabolomicsMetabolomic Analysis of Candida albicans under Metal-based anti-fungal strategy

Based on a unique pathogen iron interplay mechanism, this work establishes a new therapeutic paradigm targeting iron homeostasis at the host-pathogen interface via sequential metabolic priming, offering a broadly applicable strategy to reprogram resource asymmetry and combat fungal infection.

2026-05-10 | MTBLS13715 | MetaboLights
GenomicsTranscription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites [GP5d/siRAD21 ChIP-Seq experiments]
During cell division, transcription factors (TFs) are removed from chromatin twice, during DNA synthesis, and during condensation of chromosomes. How TFs can efficiently find their sites following these stages has been unclear. Here, we have analyzed the binding pattern of expressed TFs in human col...
ORGANISM(S): Homo sapiens 
2013-09-28 | E-GEOD-51234 | biostudies-arrayexpress
MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
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