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ProteomicsProteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection
Infection with Echinococcus granulosus, a life-threatening zoonotic parasite, can remain asymptomatic for a long time; it is generally detectable only in the advanced stages, which delays treatment in most patients. Here, we aimed to determine what E. granulosus infection does to the host organs and...
ORGANISM(S): Echinococcus granulosus 
2024-11-07 | PXD050653 | Pride
Echinococcus granulosus infection parasite-host interaction proteomics hepatic lesions 
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
2021-08-27 | PXD028167 |
Proteomicsthe proteomics of IGFBP6 in endothelial cells (HUVECs)
To unravel the direct mechanism of the anti-inflammatory effects of IGFBP6 in ECs, we analysed HUVECs treated with either adenovirus-Flag-IGFBP6 (Ad-IGFBP6) or control adenovirus (Ad-NC). We precipitated IGFBP6 from overexpressed ECs followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-13 | PXD052204 |
ProteomicsProteomic analysis of the sperm from Catsperh/tmem262 knock-out mice(WuJianping lab)
We fractionated mouse sperm proteomes using high-pH HPLC, followed by DDA-based spectral library generation. Quantitative DIA analysis was then applied to compare proteomic profiles between Tmem262-/- and WT mice, enabling deep and accurate protein quantification.
ORGANISM(S): Mus Musculus 
2025-12-18 | PXD072173 |
ProteomicsSystematic Identification and Analysis of Lysine Succinylation in Strawberry Stigmata
Strawberry is an important economic crop in the world, and strawberry stigmata are vital to promote pollen germination and allow pollen tubes to enter into stigma tissue. Post-translational modification (PTM) of proteins can significantly affect protein structure and function, and plays a very impor...
ORGANISM(S): Fragaria Vesca 
2017-12-15 | PXD008475 |
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056588 |
ProteomicsMS assay of proteins after CO-IP with GPNMB antibody in hippocampus area
Three mice were excised at day 7 after pilocarpine treatment to induce abundant GPNMB expression (Figures 1 and 2). Hippocampal proteins were extracted and pulled down by anti-GPNMB immunoprecipitation for mass-spectrometer assay.
ORGANISM(S): Mus Musculus 
2025-07-21 | PXD066376 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
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