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ProteomicsHuman BRS3 receptor activation LC-MSMS
Bombesin-like receptor 3 (BRS3), an orphan G protein–coupled receptor (GPCR), plays important roles in our biological system while the exact mechanisms behind are less known. To get insights of biological effects on BRS3 activation, we utilized quantitative proteomics approach to explore the dynamic...
ORGANISM(S): Homo sapiens (Human) 
2020-02-25 | PXD017104 | Pride
Human brs3 lc-msms 
ProteomicsTargeted Depletion of Monocyte/Macrophage Suppresses Aortic Dissection with the Spatial Regulation of MMP-9 in the Aorta
The peptide samples were analyzed by LC-MS/MS with a Q-Exactive mass spectrometer (Thermo Fisher, MA, USA) equipped with EASY-nLC 1200 liquid chromatography. The spectrometer was controlled by Xcalibur software, version 4.0 (Thermo Fisher, MA, USA). The peptides were separated on a C18 capillary col...
ORGANISM(S): Mus Musculus 
2020-11-18 | PXD022592 |
ProteomicsEx vivo lung perfusion enhances donor lung preservation in mice via Hippo signaling activation
Ex vivo lung perfusion (EVLP) is a promising technique that allows organ preservation and repair, increasing the number of marginal donor lungs for lung transplantation. This study aimed to establish an EVLP model in mice, and to unveil the molecular mechanisms responsible of EVLP beneficial effects...
ORGANISM(S): Mus Musculus 
2025-07-16 | PXD066193 |
ProteomicsCSTB increases autophagic flux by sustaining the proteolytic activity of Cathepsin B and fuels glycolysis in pancreatic cancer
Cathepsins interact with CSTB were analysed by LC/MS
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037970 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
TranscriptomicsYAP Inhibition in HCC cells (Hep3B)
siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA. Loss of contact inhibition and anchorage-independent growth are hallmarks of cancer cells. In this context, frequent inactivation of the Hippo pathway and subsequent nuclear enrichment of the transcripti...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-35004 | biostudies-arrayexpress
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