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ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
ProteomicsSerum Metabolomics in Patients with Ocular Diseases
Serum metabolomics in patients with ocular diseases is a fascinating and emerging field of study. It involves analyzing the metabolites in blood serum to understand the biochemical processes and pathways associated with various eye conditions. This approach provides a deeper insight into the pathoph...
ORGANISM(S): Homo Sapiens 
2024-01-24 | PXD048826 |
ProteomicsSIRT5-Mediated FDX1 Desuccinylation Confers Cuproptosis Resistance in Lung cancer
Cuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcino...
ORGANISM(S): Homo Sapiens 
2026-04-17 | PXD077292 |
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