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MetabolomicsThe Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism
The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active ...
2017-04-24 | MTBLS435 | MetaboLights
ProteomicsSystematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation
In this study, we systematically integrated proteome and acetyl proteome (acetylome) approaches to investigate the characteristics of renal proteins in a CaOx crystal rat model. We aimed to understand the pathogenesis of kidney calculi and delineate the landscape of acetylation within kidney calculi...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD050342 | Pride
Kidney calculi  acetylation  proteomics 
ProteomicsConotoxin Exploitation from Conus betulinus
Employing Conus betulinus as a representative, we sequenced and assembled the first Conus genome. After integration of multi-omics data, we provide novel insights into the genetic central dogma of conotoxins, assuming a number ratio of ~1:1:10s for genes/transcripts/peptides.
ORGANISM(S): conus betulinus 
2021-09-08 | PXD014892 | Pride
Conus  genome  conotoxins  multi-omics  transcript  proteomics  peptide 
ProteomicsCleavable Hydrophobic Derivatization Strategy for Enrichment and Identification of Phosphorylated Lysine Peptides
Herein, a cleavable hydrophobic derivatization (CHD) strategy was established for the enrichment and identification of pLys peptides. By CHD, 2,5-dioxopyrrolidin-1-yl-3-(decyldisulfanyl)propanoate (Dec-disulf-NHS) was synthesized to react with lysine dephosphorylated peptides, and then the derived p...
ORGANISM(S): Escherichia Coli 
2019-02-12 | PXD012682 |
ProteomicsIntegrative Comparative Proteomics Identifies Core Differentially Expressed Proteins and Pathways for Drought Tolerance by Exploiting Contrasting Rice Varieties
More tightly coordinated response was revealed at the protein level in the tolerant varieties by proteomic analysis. Carbohydrate metabolism, redox homeostasis and protein transport were found activated in the tolerant varieties in functional enrichment analysis; while photosynthesis was suppressed....
ORGANISM(S): Oryza Sativa 
2026-01-11 | PXD072923 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres for analysis of N-phosphoproteome-
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Homo Sapiens 
PXD021067 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres enabled comprehensive analysis of N-phosphoproteome
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Escherichia Coli 
2020-02-07 | PXD017423 |
ProteomicsNovel Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multi-Omics Analysis
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumour type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC is essential for the development of novel therapeutics. Here, we constructed two independent cohorts fr...
ORGANISM(S): Homo Sapiens 
2022-04-13 | PXD033206 |
ProteomicsUnveiling EMC6 as a Novel Pathogenic Determinant in hepatocellular carcinoma: Orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13
The endoplasmic reticulum (ER) membrane protein complex (EMC) is an ER multiprotein complex that affects a wide range of pathophysiological processes. Recently, the function of EMC6, a subunit of EMC, has been attracting attention for its role in cancers. However, research on EMC6 in the context of ...
ORGANISM(S): Mus Musculus 
PXD067920 |
ProteomicsProtein differential profiling of OTUB1 knockout osteoblasts
This project is to figure out the differential proteins in control and OTUB1 knockout osteoblast cells
ORGANISM(S): Mus Musculus 
2023-01-17 | PXD039507 |
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