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GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
ProteomicsSpatially Resolved Proteomics via Tissue Expansion
Spatially resolved proteomics is an emerging approach, however, it remains technically challenging due to the complexity of the tissue microsampling techniques and mass spectrometry analysis of nanoscale specimen volumes. Here, we describe an expansion proteomics method ProteomEx, a combination of t...
ORGANISM(S): Mus <genus> 
2022-11-04 | PXD037950 |
ProteomicsProteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target
The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062163 |
ProteomicsComprehensive mass spectral libraries of human thyroid tissue and cells
We established deep-coverage thyroid-specific spectral libraries encompassing over 12,000 proteins, including samples from nine types of thyroid primary and lymph node metastases tissues and fifty thyroid cancer cell lines.
ORGANISM(S): Homo Sapiens 
PXD051051 |
ProteomicsSpatial distribution of the proteome in human body and cancers
The ddaPASEF and diaPASEF data were acquired from over 60 types of human specimens. Based on these, the consensus spectral libraries were generated and used in subsequent DIA analysis to demonstrate a quantitative human proteome map and discover potential cancer biomarkers.
ORGANISM(S): Homo Sapiens 
PXD077178 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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