Sort   by:  
 Page size 
ProteomicsCRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation
N-degron pathway plays an important role in the protein quality control and maintenance of cellular protein homeostasis. ZER1 and ZYG11B, the substrate receptors of the Cullin 2-RING E3 ubiquitin ligase (CRL2), recognize N-terminal (Nt) glycine degrons and participate in the Nt-myristoylation qualit...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037312 | Pride
N-terminal acetylation Nt-ser Crl2zer1/zyg11b 
UnknownCD97-directed CAR-T cells with enhanced persistence eradicate acute myeloid leukemia in diverse xenograft models.
Not available
S-EPMC12208345 | biostudies-literature
UnknownMEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB.
Not available
S-EPMC11496645 | biostudies-literature
UnknownDevelopment and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies.
Not available
S-EPMC10290401 | biostudies-literature
UnknownTissue-Resident Macrophage-Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p-TBK1.
Not available
S-EPMC12866865 | biostudies-literature
UnknownmKmer: an unbiased K-mer embedding of microbiomic single-microbe RNA sequencing data.
Not available
S-EPMC12100620 | biostudies-literature
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
2021-08-27 | PXD028167 |
ProteomicsArginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm ...
ORGANISM(S): Homo Sapiens 
2021-05-17 | PXD018458 |
ProteomicsERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases for regulating PD-1 stability have been reported, deubiquitinase (DUB) governing PD-1 homeostasis to modulate tumor immunotherapy...
ORGANISM(S): Homo Sapiens 
2023-03-17 | PXD040671 |
Sort   by:  
 Page size