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ProteomicsFinding the LC3-interactors in senescent human A549 cells during influenza A virus infection
To screen age-related regulators of mitophagy, we examined LC3-interacting proteins by proximity-dependent biotin identification. LC3B was cloned into a mammalian expression vector tagged with a mitochondrial OMM-targeted APEX2 (mito-APEX) label for proximity-based identification of LC3-interacting ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD057110 | Pride
Influenza a virus Lc3 Ifection Senescent human cells 
MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
ProteomicsThe association between baseline serum lipids and renal outcome in microscopic polyangiitis patients
ANCA associated vasculitis(AAV) is a systemic vasculitis of small vessels, characterzied by injury of vascular endothelial cells induced by abnormally activated neutrophils. Microscopic polyangiitis (MPA) is a member of AAV with a high risk of kidney involvement. Blood lipid disorder promotes endoth...
ORGANISM(S): Homo sapiens (Human) 
2025-01-06 | PXD045969 | Pride
Plasma 
ProteomicsQuantitative proteomic analysis of whole protein in three melanoma samples of 92.1, 92.1-A and 92.1-B
A total of 6081 proteins were identified in this study, of which 5267 proteins contained quantitative information. If taking 1.2 times as the change threshold and t-test p-value < 0.05 as the standard, the expression of 335 proteins in 92.1-a / 92.1 comparison group was up-regulated and 302 proteins...
ORGANISM(S): Homo sapiens (Human) 
2022-03-21 | PXD032215 | Pride
92.1 cells Proteomic analysis Orthotopic and ectopic transplantation models of uveal melanoma 92.1-a and 92.1-b cells P62 protein 
MetabolomicsThe enhancing therapeutic effect of neonatal jaundice by bifidobacterium through regulating inflammation and gut microbiota in combination with phototherapy—a randomized controlled trial

Hyperbilirubinemia is one of the most common diseases in neonates, and phototherapy is currently the most commonly used treatment in medicine, but previous studies have found that phototherapy can lead to changes in the intestinal flora of jaundice neonates, especially bifidobacteria. The focus o...

2026-03-26 | MTBLS14123 | MetaboLights
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
UnknownComparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism.
Not available
S-EPMC10658267 | biostudies-literature
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