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MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsTargeting SKAP2-modulated cytoskeleton remodeling restores sperm motility
Our work recognized heterogeneous nuclear ribonucleoprotein R (hnRNPR) is a master regulator of m6A-dependent pre-mRNA splicing. Genetic mutation in HNRNPR leads to asthenoteratozoospermia in both humans and mice, culminating in complete sterility. Mechanistically, genetic ablation of Hnrnpr manifes...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-13 | PXD067981 | Pride
Lc-ms 
ProteomicsA simplified and efficient extracellular vesicles-based proteomics strategy for early diagnosis of colorectal cancer
In this work, we have developed a simplified, fast and efficient EVs-based proteomics strategy to enable biomarker discovery for early diagnosis of CRC. By covalent conjugation of an EV-targeting probe, DSPE, to agarose beads, we achieved one-step enrichment of EVs from plasma fluids in 10 minutes w...
ORGANISM(S): Homo Sapiens 
PXD054231 |
Genomicsena-DATASET-DUKE-NUS-01-04-2016-09:56:06:868-175 - samples
CCA targeted sequencing
EGAD00001001994 | EGA
Genomicsena-DATASET-DUKE-NUS-28-03-2016-04:29:04:072-192 - samples
Cholangiocarcinoma whole genome sequencing data
EGAD00001001988 | EGA
Genomicsena-DATASET-DUKE-NUS-05-12-2017-07:28:25:856-358 - samples
This dataset contains whole genome sequencing FASTQ data for 12 cholangiocarcinoma tumor samples, and their matched normal samples. These 12 samples are in addition to 59 samples available in dataset EGAD00001001988, and consist of patients from Thailand, Romania, and Singapore. Paired-end sequencin...
EGAD00001003834 | EGA
GenomicsWhole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clus...
EGAS00001001653 | EGA
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