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TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
ProteomicsHEK293T MS - Representing dynamic biological networks with multi-scale probabilistic models
As an example of a comprehensive model of signal transduction, we provide a Wnt network that shows remarkable robustness under a range of phenotypical and pathological conditions. Its simulation allows the clarification of controversially discussed molecular mechanisms of Wnt signalling by predictin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011835 | Pride
Human Rac1 St-rna knockdown Hek293t Jnk2 Jnk1 
TranscriptomicsHematopoietic cells-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury
Chronic liver injury triggers complications such as liver fibrosis and hepatocellular carcinoma (HCC), which are associated with alterations in distinct signaling pathways. Of particular interest is the interaction between mechanisms controlled by IKKγ/NEMO, the regulatory IKK subunit, and Jnk activ...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59601 | biostudies-arrayexpress
TranscriptomicsJNK2 inhibits mammary luminal cell commitment
JNK2 inhibits mammary luminal cell commitment
ORGANISM(S): Mus musculus 
2015-10-01 | GSE40226 | GEO
TranscriptomicsGenome-wide analysis of gene expression in jnk1-/-jnk2-/- immortalized mouse embryonic fibroblasts compared to wildtype counterparts co-cultivated with differentiating keratinocytes
Analysis of JNK-dependent fibroblast-derived soluble factors at gene expression level. The hypothesis tested in the present study was that loss of c-Jun N-terminal kinases 1 and 2, JNK1 and JNK2, in MEFs causes a strong alteration of the gene expression program coding for soluble factors, which prom...
ORGANISM(S): Mus musculus 
2013-11-26 | E-GEOD-48612 | biostudies-arrayexpress
GenomicsMus musculus
JNK2 inhibits mammary luminal cell commitment
PRJNA173707 | ENA
UnknownmiR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury.
Not available
S-EPMC8656235 | biostudies-literature
UnknownStructural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.
Not available
S-EPMC4306959 | biostudies-literature
UnknownJNK2 downregulation promotes tumorigenesis and chemoresistance by decreasing p53 stability in bladder cancer.
Not available
S-EPMC5085214 | biostudies-literature
UnknownJNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.
Not available
S-EPMC7181303 | biostudies-literature
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