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TranscriptomicsTranscription profiling of human CD4 T cells and CD8 T cells were obtained from peripheral blood mononuclear cells of previously untreated patients with CLL and healthy individuals reveals chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.
To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic leukemia (CLL) with those from age-matched healthy donors. Although the cells analyzed were not part of the...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8835 | biostudies-arrayexpress
TranscriptomicsComparison of miRNA expression in Dickkopf1-expressing versus control newborn mouse skin
miRNA expression was compared in skin from control newborn mice and littermate mice ectopically expressing the potent secreted WNT inhibitor Dickkopf 1 (DKK1) in the epidermis. DKK1 completely suppresses hair follicle development. Multiple miRNAs were identified that reproducibly produced signals ab...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-4723 | biostudies-arrayexpress
TranscriptomicsA putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. An experimental purification in which a presumed RNA binding protein was used for an RNA immunoprecipitation and microarray analysis (RIP-CHIP). Total cell extracts w...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-16942 | biostudies-arrayexpress
TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse immature pDC and pDC activated with CpG 1826 and influenza virus PR8
CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC; We used microarrays to detail the global progr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD
Comparison of lung function in C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD.
ORGANISM(S): Mus musculus 
2007-03-08 | E-MEXP-855 | biostudies-arrayexpress
TranscriptomicsUntreated and iron-treated ARPE-19 cell gene expression
To characterize the potential molecular pathway(s) affected by iron treatment and identify the one(s) responsible for C3 induction, we performed a whole genome microarray on untreated ARPE-19 cells and cells treated with 250 ?M FAC for 48h/2d. Gene expression was compared between untreated and FAC-t...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67603 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Sequencing of testis tissue from 3 mouse species and their immediate crosses
We performed an inter-species comparison of murine spermatogenesis using the inbred strains C57B6J, CAST/EiJ and CAROLI/EiJ to investigate the cell type-specific evolution of gene expression levels among closely related species. We also used F1 crosses of C57B6J and CAST/EiJ to investigate context-s...
ORGANISM(S): Mus musculus 
2023-12-11 | E-MTAB-11602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse islet growth after partial pancreatectomy and exendin-4 Treatment
Diabetes mellitus results from an inadequately functioning beta-cell mass. In the adult pancreas, beta-cell mass is dynamic, increasing to meet metabolic demands and decreasing with metabolic or injury insults. Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor agonist that augments beta-cell m...
ORGANISM(S): Mus musculus 
2005-12-01 | E-CBIL-5 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MDAMB231 breast cancer cells by Parvin-beta in 2D vs 3D culture conditions
Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transc...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9747 | biostudies-arrayexpress
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