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TranscriptomicsTranscription profiling of rat testes following exposure to mono-(2-ethylhexyl) phthalate
In rodent models, phthalate exposure alters both the fetal and pubertal testis, but the resulting histopathological changes are divergent. This suggests that the underlying molecular and cellular phthalate mechanism may be age-dependent. Using genome-wide expression profiling of acutely-exposed ra...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4514 | biostudies-arrayexpress
ProteomicsTRIM9 and TRIM67 interactome using the BioID approach
TRIM9 and TRIM67 are two brain enriched E3 uiquitin ligases that are critical to neuronal form and function both during embryonic development and in adult-born neurons. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known.Using the BioID approach w...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021758 | Pride
Embryonic cortical neurons Orbitrap fusion lumos 
TranscriptomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions [Affymetrix]
Expression data from 3134 mouse mammary epithelial cell line -/+ Tet-inducible chromatin remodeler mutant variants ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-66544 | biostudies-arrayexpress
ProteomicsDasatinib for the treatment of gastric cancer
Gastric cancer (GC) represents a major health problem, remaining the fifth most common type of cancer and the third leading cause of cancer-related death worldwide with only few targeted therapies available to date. The positive effect of kinase inhibitors on many different types of cancers has prom...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012953 | Pride
Dasatinib Src kinases Gastric cancer Kinobeads 
TranscriptomicsZebrafish heart regeneration
Ischemic cardiopathy is the leading cause of death in the world, for which efficient regenerative therapy is not currently available. In mammals, after a myocardial infarction episode, the damaged myocardium is replaced by scar tissue featuring collagen deposition and tissue remodelling with negligi...
ORGANISM(S): Danio rerio 
2010-03-09 | E-GEOD-17993 | biostudies-arrayexpress
TranscriptomicsWaves of early transcriptional activation and pluripotency program initiation along human preimplantation development.
The events regulating human preimplantation development are still largely unknown, due to scarcity of material, ethical and legal limitations, and lack of reliable techniques to faithfully amplify the transcriptome of a single cell. Nonetheless, knowledge in human embryology is gathering renewed int...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29397 | biostudies-arrayexpress
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (ChIP-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53583 | biostudies-arrayexpress
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (Dnase-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53584 | biostudies-arrayexpress
ProteomicsThe nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
Domain level interactions between the ISWI remodeler SNF2h and reconstituted mononucleosomes were probed by EDC crosslinking under different biochemical conditions: ADP, ADP-BeFx, ADP-BeFx with LANA peptide added (which binds at the acidic patch). A semi quantitative approach was used to monitor do...
ORGANISM(S): Xenopus Laevis (ncbitaxon:8355) Homo Sapiens (ncbitaxon:9606) 
2018-03-07 | MSV000082136 | MassIVE
TranscriptomicsProfiling of single murine bronchioalveolar stem cells
Murine bronchioalveolar stem cells play a key role in pulmonary epithelial maintenance and repair but their molecular profile is poorly described so far. In this study, we used antibodies directed against Sca-1 and CD34, two markers originally ascribed to pulmonary cells harboring regenerative poten...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52215 | biostudies-arrayexpress
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