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Transcriptomics"Calling Cards" for DNA-binding proteins in mammalian cells
The ability to chronicle transcription factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell fate decisions. We describe a method for permanently recording protein-DNA interactions in mammalian cells. We endow transcri...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-34791 | biostudies-arrayexpress
GenomicsMultiplexed identification of the genomic targets of DNA-binding proteins
Transcription factors direct gene expression, and so there is much interest in mapping their genome-wide binding locations. M-BM- Current methods do not allow for the multiplexed analysis of TF binding, and this limits their throughput. We describe a novel method for determining the genomic target g...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-18 | E-GEOD-27381 | biostudies-arrayexpress
UnknownPhase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Not available
S-EPMC4348638 | biostudies-literature
GenomicsTargets of Ty3 transposition in Saccharomyces cerevisiae
The goal of these experiments was to define the targets of Ty3 transposition in Saccharomyces cerevisiae. Ty3 is a retroviruslike element that is found at the transcription initiation site of chromosomal tRNA genes. A Ty3 that can be induced by growth in galactose-containing medium and which was ma...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-02 | E-GEOD-31820 | biostudies-arrayexpress
UnknownDepletion of Key Meiotic Genes and Transcriptome-Wide Abiotic Stress Reprogramming Mark Early Preparatory Events Ahead of Apomeiotic Transition.
Not available
S-EPMC5080521 | biostudies-literature
ProteomicsUltra-sensitive platelet proteome maps the O-glycosylation landscape and identifies a new form of domain-specific O-fucosylation
Platelet activation induces the secretion of proteins that promote platelet aggregation and inflammation. However, detailed analysis of the released platelet proteome is hampered by platelets’ tendency to pre-activate during their isolation and a lack of sensitive protocols for low abundance releasa...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD045535 | Pride
O-glycosylation Platelet 
ProteomicsDiurnal glycogen metabolism drives rhythmic liver protein secretion
The liver secretes most circulating proteins, which are critical for inter-organ communication and systemic energy homeostasis. However, the regulatory mechanisms governing hepatic protein secretion are largely unknown. Using proteomics approaches in humans and mice, we here demonstrate that hepatic...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-06 | PXD058564 | Pride
Glycosylation Circadian Secretion Liver Plasma 
ProteomicsProteomics of Skin Proteins in Psoriasis
Herein we demonstrate the efficacy of an unbiased proteomics screening approach for studying protein expression changes in the KC-Tie2 psoriasis mouse model, identifying multiple protein expression changes in the mouse and validating these changes in human psoriasis. KC-Tie2 mouse skin samples (n=3...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-30 | PXD001387 | Pride
Psoriasis Trangenic mouse Lc-msms 
TranscriptomicsCharacterisation of the whole blood mRNA transcriptome in Holstein-Friesian and Jersey calves in response to gradual weaning
The objectives of the study were to use RNA-Seq to examine the effect of (i) breed and (ii) gradual weaning, on the whole blood mRNA transcriptome of artificially reared Holstein-Friesian and Jersey calves. The calves were gradually weaned over 14 days (day (d) -13 to d 0) and mRNA transcription was...
ORGANISM(S): Bos taurus 
2016-08-19 | E-GEOD-76841 | biostudies-arrayexpress
UnknownCrystal structures of E. coli native MenH and two active site mutants.
Not available
S-EPMC3630204 | biostudies-literature
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