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ProteomicsCharacterization of Integrator module INTS10-INTS13-INTS14 and its connection to the cleavage module Part I
Chemical cross-linking coupled to mass spectrometry was used to study the complex between the Integrator complex subunits INTS13 (Asunder) and INTS14. Cross-linking was performed using disuccinimidyl suberate (DSS).
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD015682 | Pride
Chemical cross-linking  dss  structural proteomics  integrator complex 
ProteomicsCharacterization of Integrator module INTS10-INTS13-INTS14 and its connection to the cleavage module Part II
Chemical cross-linking coupled to mass spectrometry was used to study the complex between the Integrator complex subunits INTS4, 9, 11, and a partial segment of INTS13 containing the C-terminal region (termed CMBM). Cross-linking was performed using disuccinimidyl suberate (DSS).
ORGANISM(S): Homo sapiens (Human) 
2020-06-18 | PXD017996 | Pride
Chemical cross-linking  dss  structural proteomics  integrator complex 
ProteomicsTAP-MS of human Integrator subunits INTS10 and INTS13
Using a combination of proteomics, interaction studies and structural characterization we show that the INTS10-13-14 module of INT binds several transcriptional regulators and gene-specific transcription factors, whichcould form the molecular basis for a part of INT's gene specificity.
ORGANISM(S): Homo sapiens (Human) 
2024-06-27 | PXD041374 | Pride
Human Integrator Tap-ms 
ProteomicsTAP-MS of human BRAT1 and WDR73
Using a combination of proteomics, interaction studies and structural characterization we show that WDR73 and BRAT1 are interactors of the heterodimer INTS9-11 of INT. Both proteins are involved in the stability and formation of the cleavage module of INT consisting of INTS4-9-11.
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD044324 | Pride
Lc-ms/ms 
TranscriptomicsTranscriptome partitioning for mRNA translation in hypoxia
Protein synthesis belongs to the most energy consuming processes in the cell. Lowering oxygen tension below normal (hypoxia) causes a rapid inhibition of global mRNA translation due to the decreased availability of energy. Interestingly, subsets of mRNAs pursue active translation under such circumst...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-49029 | biostudies-arrayexpress
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