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As a key structural component of the chromatin of higher eukaryotes, linker histones (H1s) are involved in stabilizing the folding of extended nucleosome arrays into higher-order chromatin structures and function as a gene-specific regulators of transcription in vivo. The H1 C-terminal domain (CTD) ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-08-12 | PXD032292 | Pride
Persistent HIV reservoirs in CD4⁺ T-cells impede efforts to cure HIV infection. We identified overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T-cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 with the FD...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD061146 | Pride
5 day q.d. treatment by oral gavage of SD rats using 0, 200, 400 or 800 mg/kg/day of the peroxisome proliferator clofibrate. Livers were removed, RNA was isolated, and Cy3/Cy5 probes generated for 2-channel microarray experiments.
ORGANISM(S): Rattus norvegicus 
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