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ProteomicsIntegrin adhesion complex (IAC) analysis from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix and interacts with integrin adhesion receptors. Integrin adhesion complexes formed by HPDE cells (H6c7), with and without expression of mutant KRa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027827 | Pride
Pdac Integrin 
ProteomicsProteomic analysis of integrin adhesion complex disassembly induced by nocodazole
To explore the dynamics of integrin adhesion complex disassembly, isolated adhesion complexes from U2OS cells were subjected to mass spectrometry based proteomic analysis. U2OS cells were allowed to spread on FN, treated with nocodazole for 4 hours to disrupt microtubules. To coordinate microtubule-...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002129 | Pride
Human Integrins U2os cells Time course 
ProteomicsCell-derived extracellular matrix (CDM) from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix. The extracellular matrix produced by HPDE cells (H6c7), with and without expression of mutant KRas G12V, was analysed by LC-MSMS
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027803 | Pride
Ecm Pdac 
ProteomicsA combined transcriptomic and proteomic approach to identify toxicity pathways in early-life stages of Japanese medaka (Oryzias latipes) exposed to 1,2,5,6- tetrabromocyclooctane (TBCO)
Currently, the novel brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO), is considered as a potential replacement for hexabromocyclododecane (HBCD). As such, use of TBCO could increase significantly in the near future. Therefore, this study investigated the toxicity of TBCO in order to...
ORGANISM(S): Oryzias latipes (Japanese rice fish) (Japanese killifish) 
2017-06-29 | PXD003823 | Pride
Novel brominated flame retardant  rna-seq  eye development  gene ontology  pathway enrichment 
ProteomicsSecretome from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix. The proteins and extracellular matrix secreted by HPDE cells (H6c7), with and without expression of mutant KRas G12V, was analysed by LC-MSMS
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027823 | Pride
Ecm Pdac 
TranscriptomicsTranscriptional profiling of human kidney samples to discover gene signatures of progression and metastasis in renal cell cancer
In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene exp...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-15641 | biostudies-arrayexpress
UnknownRadiation combined with Macrophage Depletion Promotes Immunity and Potentiates Checkpoint Blockade
Not available
S-SCDT-88789_2_1540197428_jats | biostudies-other
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
GenomicsdeCODE Genetics study on genes contributing to nicotine dependence in humans

A genome-wide association study on smoking behavior and nicotine dependence in Icelandic smokers, assessed by the number of cigarettes smoked per day, smoking initiation and degree of dependence on nicotine.

The number of cigarettes smoked per day was ascertained through questionnaires giv...

phs000393.v1.p1 | EGA
GenomicsA Genome-Wide Association Study of Peripheral Arterial Disease

The Electronic Medical Record Phenotypes and Community-engaged Genomic Association Study aims to identify genetic variants mediating susceptibility to peripheral arterial disease (PAD). The study leverages a biorepository of blood samples of 1688 PAD cases and 1649 controls, and the electronic ...

phs000203.v1.p1 | EGA
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