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TranscriptomicsArray-based comparative genomic hybridisation analysis at 1Mb resolution of 44 pilocytic astrocytomas
Pilocytic astrocytomas (PAs), WHO Grade I, are one of the most frequently occurring childhood brain tumors. We have used microarray comparative genomic hybridization (aCGH) at 1Mb resolution to study copy number changes in a series of PAs (n=44). Single hybridization per case. 44 pilocytic astrocyto...
ORGANISM(S): Homo sapiens 
2008-04-28 | E-GEOD-11263 | biostudies-arrayexpress
TranscriptomicsA novel way for enriching human melanoma precursor cells to identify cellular targets for antineoplastic therapy
Metastatic melanoma is difficult to treat and is resistant to most current therapies. We hypothesized that stem cell related pathways may play a role in melanoma growth since stem cells and cancer cells share essential properties. Lately, the ABC transporter, ABCB5, as well as Cripto-1, CD20, CD133...
ORGANISM(S): Homo sapiens 
2011-12-29 | E-GEOD-20469 | biostudies-arrayexpress
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
GenomicsWhole genome study of Hurthle cell thyroid carcinoma
Oncocytic thyroid carcinoma, also known as Hürthle cell thyroid carcinoma, accounts for only a small percentage of all thyroid cancers. However, this malignancy often presents at an advanced stage and poses unique challenges to patients and clinicians. Surgical resection of the tumor accompanied in...
EGAS00001000940 | EGA
TranscriptomicsDirect genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (human)
Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mese...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57518 | biostudies-arrayexpress
GenomicsMEN1 Mutational Analysis in Hurthle Cell Thyroid Carcinoma - samples
This dataset includes 2 pairs of tumour/normal whole genome sequence data as well as MEN1 gene targeted sequencing of an additional 87 specimens.
EGAD00001001085 | EGA
TranscriptomicsICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer
Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeu...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-36924 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 269 individuals from three geographically distinct human populations to investigate copy number variation
We conducted comparative genome hybridization experiments to catalogue the common copy number variation evident between 269 individuals from three geographically distinct human populations (Yoruban, Chinese/Japanese, European) against a single reference individual.
ORGANISM(S): Homo sapiens 
2006-07-31 | E-TABM-107 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-07-04-2017-10:40:02:500-10 - samples
RNA sequencing data for 170 medulloblastoma tumor samples
EGAD00001003279 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-03-01-2017-12:51:29:816-785 - samples
WGS data of medulloblastoma tumor/control pairs.
EGAD00001003127 | EGA
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