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ProteomicsJOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
Increased level of angiotensin II (Ang II) plays a central role in the development of hypertensive vascular remodeling. Here, we identify the deubiquitinating enzyme JOSD2 as a protective factor and investigate its molecular mechanism in Ang II-induced vascular remodeling. Firstly, we found that JOS...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-10 | PXD056674 | Pride
Ubiquitination Angiotensin ii Smad7 Josd2 Vascular remodeling 
ProteomicsJosephin Domain Containing 2 (JOSD2) Inhibition as Pan-KRAS-Mutation-Targeting Strategy for Colorectal Cancer
KRAS is the most common mutated oncogenes in colorectal cancer (CRC), yet effective therapeutic strategies for targeting multiple KRAS-mutations remained challenging. The prolonged protein stability of KRAS mutants contribute to their robust tumor-promoting effects, but the underlying mechanism is e...
ORGANISM(S): Homo sapiens (Human) 
2025-03-01 | PXD054525 | Pride
Deubiquitinases Ubiquitination. Josd2 Kras Colorectal cancer 
ProteomicsDeubiquitinase JOSD2 promotes non-small cell lung cancer proliferation via deubiquitylation and inactivation of LKB1
Deubiquitinases (DUBs), frequently overactivated in cancers, are associated with tumorigenesis and regarded as promising therapeutic targets. However, the underlying mechanism of DUBs promoting non-small cell lung cancer (NSCLC) are poorly understood. Through a global analysis of the contribution of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046139 | Pride
Deubiquitinases K6-linked polyubiquitination Non-small cell lung cancer Lkb1 Kinase activity Josd2 
ProteomicsProteomics analysis of JOSD2-overexpression in NIH/3T3 cells
DUBs exert their biological functions through specific substrates. Theoretically, as a substrate protein of JOSD2, its ubiquitination will be cut by JOSD2. In this regard, an analysis of ubiquitinome assay was performed to identify the potential substrates of JOSD2 in NIH/3T3 cells transfected with ...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-30 | PXD043382 | Pride
Lc-ms/ms Mouse Nih/3t3 Josd2 
GenomicsJOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
PRJNA1172292 | ENA
TranscriptomicsJOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
Increased level of angiotensin II (Ang II) plays a central role in the development of hypertensive vascular remodeling. Here, we identify the deubiquitinating enzyme JOSD2 as a protective factor and investigate its molecular mechanism in Ang II-induced vascular remodeling. Firstly, we found that JOS...
ORGANISM(S): Mus musculus 
2024-10-18 | GSE279358 | GEO
GenomicsJOSD2 promotes non-small cell lung cancer proliferation by removing K6-linked polyubiquitination from LKB1
JOSD2 promotes non-small cell lung cancer proliferation by removing K6-linked polyubiquitination from LKB1
PRJNA814993 | ENA
UnknownJOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression.
Not available
S-EPMC9281007 | biostudies-literature
UnknownThe deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Not available
S-EPMC7937685 | biostudies-literature
TranscriptomicsJOSD2 promotes non-small cell lung cancer proliferation by removing K6-linked polyubiquitination from LKB1
Deubiquitinating enzymes (DUBs), frequently overactivated in cancers, are associated with tumorigenesis and regarded as promising therapeutic targets. However, the tumor-promoting role and underlying mechanism of DUBs in non-small cell lung cancer (NSCLC) are poorly understood. Through a global anal...
ORGANISM(S): Homo sapiens 
2024-01-10 | GSE198415 | GEO
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