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ProteomicsMyofibroblast-specific Smad7 protects the pressure-overloaded heart by restraining collagen deposition and denaturation, and by inhibiting paracrine macrophage activation
Rationale: Expansion and activation of cardiac fibroblasts contributes to adverse remodeling, fibrosis and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β/Smad3 activation protects the pressure overloaded heart by preserving the matrix, sustained TGF-β activation may be...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD049057 | Pride
Heart Proteomics Macrophage Smad7 Pressure 
ProteomicsMyofibroblast-specific Smad7 protects the pressure-overloaded heart by restraining collagen deposition and denaturation, and by inhibiting paracrine macrophage activation
Rationale: Expansion and activation of cardiac fibroblasts contributes to adverse remodeling, fibrosis and dysfunction in the pressure-overloaded heart. Although early fibroblast TGF-β/Smad3 activation protects the pressure overloaded heart by preserving the matrix, sustained TGF-β activation may be...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD043577 | Pride
Heart Tgf-beta Fibrosis Smad7 
GenomicsCardiomyocyte-Specific Smad7 protects the pressure-overloaded heart, inhibiting the TbR1/Smad2/3 cascade [Smad7 knockout]
Cardiomyocyte-Specific Smad7 protects the pressure-overloaded heart, inhibiting the TbR1/Smad2/3 cascade [Smad7 knockout]
PRJNA1274464 | ENA
ProteomicsJOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7
Increased level of angiotensin II (Ang II) plays a central role in the development of hypertensive vascular remodeling. Here, we identify the deubiquitinating enzyme JOSD2 as a protective factor and investigate its molecular mechanism in Ang II-induced vascular remodeling. Firstly, we found that JOS...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-10 | PXD056674 | Pride
Ubiquitination Angiotensin ii Smad7 Josd2 Vascular remodeling 
GenomicsAs2S2 restores erythroid maturation in sf3b1-deficient zebrafish by upregulating smad7
As2S2 restores erythroid maturation in sf3b1-deficient zebrafish by upregulating smad7
PRJNA1399991 | ENA
GenomicsLinc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b
Linc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b
PRJNA416448 | ENA
GenomicsLoss of smad7 promoted the stromal-myofibroblast transition of endometrium via autophagy
Loss of smad7 promoted the stromal-myofibroblast transition of endometrium via autophagy
PRJNA1138876 | ENA
GenomicsIL22RA2 is a Smad7 target mediating alleviation of dermatitis and psoriatic phenotypes in mice
IL22RA2 is a Smad7 target mediating alleviation of dermatitis and psoriatic phenotypes in mice
PRJNA967727 | ENA
GenomicsA fine-tuned regulation of Bmp2 by Nodal/TGFβ signalling induced lncRNA-Smad7
A fine-tuned regulation of Bmp2 by Nodal/TGFβ signalling induced lncRNA-Smad7
PRJNA737443 | ENA
TranscriptomicsCardiomyocyte-Specific Smad7 protects the pressure-overloaded heart, inhibiting the TbR1/Smad2/3 cascade [Smad7 knockout]
Cardiomyocytes are the major effectors of cardiac remodeling under pressure overload, undergoing hypertrophy and contractile dysfunction in response to sustained mechanical stress. These maladaptive changes are orchestrated by transforming growth factor beta (TGF-β), a key mediator of hypertrophic a...
ORGANISM(S): Mus musculus 
2026-06-06 | GSE299451 | GEO
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