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MetabolomicsTargeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase inhibitors (PARPi), such as olaparib, have significantly improved outcomes in ovarian cancer (OC); however, therapy resistance remains a major clinical challenge. Here, we showed that glutamine metabolism was upregulated in PARPi-resistant OC cells and identified the g...

2026-04-08 | MTBLS14072 | MetaboLights
MetabolomicsNeuropeptide SP protects against colitis and linked anxiety-like behavior via gut microbiota and metabolite inositol: A multi-omics analysis of the gut-brain axis

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interaction...

2025-11-18 | MTBLS11203 | MetaboLights
UnknownSeen and not seen: How people judge ambiguous behavior during the COVID-19 pandemic.
Not available
S-EPMC9743130 | biostudies-literature
UnknownHuman-anchored longitudinal comparison of generative AI with a bias-calibrated LLM-as-judge.
Not available
S-EPMC12863567 | biostudies-literature
UnknownLooking for the negative: Depressive symptoms in adolescent girls are associated with sustained attention to a potentially critical judge during in vivo social evaluation.
Not available
S-EPMC7083081 | biostudies-literature
TranscriptomicsReal-time quantitative PCR analysis of rat diaphragm before and after acute cervical spinal cord injury
Male Sprague Dawley adult rats were subjected to a cervical hemisection at C2 (C2HS). Costal diaphragm (both ipsilesional and contralesional sides) were assessed under control conditions (sham surgery) and at 1 and 7 days post-C2HS. We used SA Biosciences Rat Skeletal Muscle Development and Disea...
ORGANISM(S): Rattus norvegicus 
2013-12-18 | E-GEOD-45021 | biostudies-arrayexpress
TranscriptomicsPlatform comparison and transcription profiling of human cell lines on three array platforms (Affymetrix GeneChip Human Genome U133 Plus 2.0, GE Healthcare/Amersham Biosciences UniSet Human 20K I Bioarray and Agilent Whole Human Genome Oligo Microarray)
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). We compared the relative precision and accuracy of expression measurements obtained from three different state-of-the-art commercial short and long-oligonucleotide micro...
ORGANISM(S): Homo sapiens 
2005-11-01 | E-MEXP-467 | biostudies-arrayexpress
UnknownEquity focused workshops: Developing a supplementary method to judge the equity of health interventions.
Not available
S-EPMC12315834 | biostudies-literature
UnknownLow Muscle Mass and Radiodensity Associate with Impaired Pulmonary Function and Respiratory Complications in Patients with Esophageal Cancer.
Not available
S-EPMC10023327 | biostudies-literature
TranscriptomicsPoly(A)-Specifc Ribonuclease 1 (PARN-1) Overexpression in Procyclic T. brucei
We sought to determine the effect of TbPARN-1 overexpression on global mRNA steady-state levels in T. brucei. The mRNA expression profile of tet-induced TbPARN-1 OvEx procyclic cells was compared to the mRNA profile of control cells (expressing tet-induced TAP tag alone) by microarray analysis. S...
ORGANISM(S): Trypanosoma brucei 
2010-03-04 | E-GEOD-20593 | biostudies-arrayexpress
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