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ProteomicsSkeletal Muscle Proteome of Cachectic Pancreatic Cancer Patients
Cancer cachexia is a multifactorial condition characterized by skeletal muscle loss that impairs longevity and quality of life of the vast majority of cancer patients. However, the ability to develop therapeutic strategies to counter cachexia is impeded by the limited understanding of the underlying...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD047838 | Pride
Cachexia Orbitrap fusion lumos Skeletal muscle Rectus abdominis Pancreatic cancer Pdac 
ProteomicsBlocking muscle wasting via deletion of the muscle specific E3 ligase MuRF1 impedes pancreatic tumor growth – ubiquitome dataset
Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigated the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC) ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-15 | PXD039151 | Pride
Proteasome system Cancer cachexia Mus musculus Murf1 Muscle wasting Pancreatic cancer 
ProteomicsBlocking muscle wasting via deletion of the muscle specific E3 ligase MuRF1 impedes pancreatic tumor growth - proteome dataset
Cancer-induced muscle wasting reduces quality of life, complicates or precludes cancer treatments, and predicts early mortality. Herein, we investigated the requirement of the muscle-specific E3 ubiquitin ligase, MuRF1, for muscle wasting induced by pancreatic cancer. Murine pancreatic cancer (KPC) ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-15 | PXD039158 | Pride
Cancer cachexia Murf1 Muscle wasting Pancreatic cancer 
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