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TranscriptomicsExpression profiling in Wild-type and C-JUN knockout MEFs treated with IFNgamma and cycloheximide
STAT1 is the major transcription factor (TF) driving response to exposure to IFNg. C-JUN is a TF which has been shown to bind with STAT1 and act as a partner TF. We have expression profiled WT and CJUN-/- MEFs in order to determine the set of IFNg genes regulated by STAT1 and C-JUN. This study was d...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-26205 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hematopoietic stem cells in the preleukemic phase from wiltype mice and mice deficient in transcription factor PU.1 to identify transcriptional changes preceding malignant transformation
Knockdown of the transcription factor PU.1 (Spi1) leads to acute myeloid leukemia (AML) in mice. We examined the transcriptome of PU.1 knockdown hematopoietic stem cells (HSC) in the preleukemic phase by linear amplification and genome-wide array analysis to identify transcriptional changes precedin...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5654 | biostudies-arrayexpress
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
Transcriptomicsc-JUN REPROGRAMS SCHWANN CELLS OF INJURED NERVES TO GENERATE A REPAIR CELL ESSENTIAL FOR REGENERATION
The striking PNS regenerative response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states, a highly unusual feature in mammals. Using mice with inactivation of Schwann cell c-Jun, we show that the injury response involves c-Jun depen...
ORGANISM(S): Mus musculus 
2012-06-13 | E-GEOD-38693 | biostudies-arrayexpress
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
UnknownVitamin D receptor (VDR) and group-specific component (GC, vitamin D-binding protein) polymorphisms in myopia.
Not available
S-EPMC3109057 | biostudies-literature
UnknownMapping micrometer-scale wetting properties of superhydrophobic surfaces.
Not available
S-EPMC6911201 | biostudies-literature
ProteomicsInvestigation upon the state of p53 as well as interaction partners, in so much as can be learned from using the multi-component v5-dTag system.
Chromatin modifications provide additional context-dependence for DNA sequence-based gene regulation. Binding sites of the transcription factor (TF) and important tumour suppressor p53 are unusually diverse with regards to their chromatin accessibility and histone modifications, suggesting different...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD033674 | Pride
Trim24 Gene regulation Chromatin P53 
ProteomicsReadout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for p53 regulation. Here, we show that the ability of...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD039553 | Pride
Trim24 p53 mouse 
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