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ProteomicsResuscitation from the viable but nonculturable state of Escherichia coli: the importance of a pyruvate sensing network
Viable but nonculturable (VBNC) organisms have been underestimated and neglected when studying dormant phenotypes. In clinical settings, VBNC cells may contribute to non-apparent infections capable of being reactivated after months or even years, as for the case of Mycobacterium tuberculosis. The la...
ORGANISM(S): Escherichia coli 
2018-11-23 | PXD009463 | Pride
Heterogeneity Metabolism Oxidative stress Scavenging 
ProteomicsFunction and Regulation of the pyruvate transporter CstA in Escherichia coli
Pyruvate is a central metabolite that connects many metabolic pathways in living organisms. To meet the cellular pyruvate requirements, Escherichia coli most likely has three pyruvate uptake systems, BtsT, YhjX and CstA. Transport studies in intact cells proved that CstA is a high specific pyruvate ...
ORGANISM(S): Escherichia coli 
2020-12-02 | PXD021798 | Pride
Catabolite repression Stationary phase Pyruvate uptake Global regulator fis 
ProteomicsProteome analysis of Corynebacterium glutamicum ATCC13032 Δefp
Bacterial translational elongation factor P (EF-P) is required during translation of proteins containing consecutive proline motifs. Several transcription and translational regulators contain polyproline motifs and therefore, EF-P might also affect levels of proteins that do not contain polyproline ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2020-04-06 | PXD014742 | Pride
Ef-p Corynebacterium glutamicum Actinobacteria Elongation factor p 
UnknownColorectal Cancer Prognosis is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Study.
Not available
S-EPMC6351956 | biostudies-literature
TranscriptomicsHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
Analysis of the transcriptional response of C. neoformans WT, cir1 mutant, hap3 mutant and hapX mutant to different iron sources. The following experimental design was adopted for the study. Within each strain, each treatment pair (low-iron, +FeCl3, +Transferrin and +Hemin; 6 pairs) were hybridized ...
ORGANISM(S): Cryptococcus neoformans 
2011-04-13 | E-GEOD-22988 | biostudies-arrayexpress
TranscriptomicsSmall non-coding RNA profiling and the role of piRNA pathway genes in the protection of chicken primordial germ cells
Background: Genes, RNAs, and proteins play important roles during germline development. However, the functions of non-coding RNAs (ncRNAs) on germline development remain unclear in avian species. Recent high-throughput techniques have identified several classes of ncRNAs, including micro RNAs (miRNA...
ORGANISM(S): Gallus gallus 
2015-04-27 | E-GEOD-60400 | biostudies-arrayexpress
TranscriptomicsProfiling ethanol-targeted transcription factors in human carcinoma cell-derived embryoid bodies.
A total of 493 differentially expressed genes were identified in response to 50 mM ethanol exposure, in which 111 of them were up-regulated and 382 were down-regulated. Gene ontology term enrichment analysis revealed that the genes are involved in the important biological processes like neurological...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-67864 | biostudies-arrayexpress
TranscriptomicsNotch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-31551 | biostudies-arrayexpress
TranscriptomicsHigh-fat diet decreases expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in adipose tissue, along with increased expression of extracellular matrix remodeling- and inflammation-related genes
We identified differentially expressed genes in epididymal white adipose tissue of high fat diet(HFD)-fed mice compared to low fat diet-fed mice using microarray analysis. Microarray analysis revealed that genes related to lipolysis, fatty acid metabolism, mitochondrial energy transduction, oxidatio...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-63198 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of mouse immature CD4SP thymocytes
RNA was isolated with the RNeasy kit (Qiagen) from electronically sorted immature CD4SP thymocytes. RNA was reverse transcribed into cDNA by oligo(dT) priming with the QuantiTect Reverse transcription kit (Qiagen). The expression of 84 key genes involved in apoptosis, or programmed cell death was pe...
ORGANISM(S): Mus musculus 
2013-07-27 | E-GEOD-49270 | biostudies-arrayexpress
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