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ProteomicsTryptophan C-mannosylation is critical for Plasmodium falciparum transmission Dataset1
C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
ORGANISM(S): Plasmodium falciparum 
2022-07-06 | PXD033470 | Pride
Glycosylation Plasmodium falciparum Ookinete Sporozoite Gametocyte Gamete Dpy19 Transmission 
TranscriptomicsMisregulation of the broad-range phospholipase C activity increases the susceptibility of Listeria monocytogenes to intracellular killing by neutrophils
Listeria monocytogenes is a facultative intracellular bacterial pathogen that tightly regulates the activities of various virulence factors during infection. A mutant strain (the plcBM-NM-^Tpro mutant) that has lost the ability to control the activity of a phospholipase C (PC-PLC) is attenuated a hu...
ORGANISM(S): Mus musculus 
2013-08-14 | E-GEOD-49820 | biostudies-arrayexpress
TranscriptomicsERK signaling regulates opposing functions of JUN family transcription factors in prostate cancer cell migration
Knockdowns of c-JUN and JUND had opposite effects on PC3 prostate cell migration. We predicted that c-JUN and JUND control the same set of cell migration genes, but in opposite directions. To test this hypothesis, mRNA with expression changes in c-JUN and JUND knockdown PC3 cell lines were compared ...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-53470 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BIX01294-treated human neuroblastoma cell line BE(2)-C
Increased activation of the serine-glycine biosynthetic pathway is an integral part of cancer metabolism that drives macromolecule synthesis needed for cell proliferation. Whether this pathway is under epigenetic control is unknown. Here we show that the histone H3 lysine 9 (H3K9) methyltransferase ...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-51512 | biostudies-arrayexpress
TranscriptomicsHOXC9-induced neuronal differentiation in human neuroblastoma BE(2)-C cells [Gene expression profiling]
Cell differentiation is an essential process of normal development by which a stem cell or progenitor cell becomes a post-mitotic, specialized cell with unique morphology and function. Also, it has long been recognized that differentiation is associated with a marked reduction in DNA damage response...
ORGANISM(S): Homo sapiens 
2013-11-03 | E-GEOD-34420 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human neuroblastoma BE(2)-C cells with MEIS2 depletion
MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cel...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-56003 | biostudies-arrayexpress
GenomicsHOXC9-induced neuronal differentiation in human neuroblastoma BE(2)-C cells [ChIP-seq analysis]
Cell differentiation is an essential process of normal development by which a stem cell or progenitor cell becomes a post-mitotic, specialized cell with unique morphology and function. Also, it has long been recognized that differentiation is associated with a marked reduction in DNA damage response...
ORGANISM(S): Homo sapiens 
2013-11-03 | E-GEOD-34419 | biostudies-arrayexpress
TranscriptomicsGene expression profile of abf1-1 mutant at 36 degrees C
The abf1-1 mutant and wild type cells were grown at 30 degrees C in YPAD until OD600 reached 1.0-1.2. The same volume of 42 degrees C preheated YPAD was added for each flask. After 45 min incubation at 36 degrees C, cells were harvested and RNA was isolated. Four repeats of microarray results are in...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-1492 | biostudies-arrayexpress
UnknownStructural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Not available
S-EPMC6212729 | biostudies-literature
TranscriptomicsAnalysis of hippocampal gene expression in adult and aged male BABL/c mice with or without running wheel access
Currently, the mechanisms behind the anti-aging effects of exercise are not understood. The presented study conducted a microarray on hippocampal samples from adult (3.5 month-old) and aged (18 month-old) male BALB/c mice that were individually housed with or without running wheels for 8 weeks. Resu...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-29075 | biostudies-arrayexpress
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