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ProteomicsOncogenic and microenvironmental signals drive cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signalling and is characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using Mx-Cre;PTPN11D61Y mice, which reflect human JMML, we show that RAS pathway activat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055845 | Pride
Ptpn11 Bcl2 Jmml Apoptosis Bcl-xl Juvenile monocytic leukemia Mcl-1 Extrinsic and intrinsic shp2 signalling Shp2 
TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
TranscriptomicsJuvenile Myelo Monocytic Leukemia (JMML) genetic screening
Dectection of somatic copy number variations from Affymetrix 6.0 SNP array
ORGANISM(S): Homo sapiens 
2015-05-11 | E-MTAB-3399 | biostudies-arrayexpress
UnknownBH3 mimetics and azacitidine show synergistic effects on juvenile myelomonocytic leukemia.
Not available
S-EPMC10776398 | biostudies-literature
UnknownGenomic determinants of chronic myelomonocytic leukemia.
Not available
S-EPMC8370480 | biostudies-literature
TranscriptomicsRET fusion genes, BCR-RET and FGFR1OP-RET, are associated with chronic myelomonocytic leukemia, display sensitivity to Sorafenib, an inhibitor of tyrosine-kinase activity and enhance monocytic differentiation
Myeloproliferative neoplasms are frequently associated with aberrant constitutive tyrosine kinase (TK) activity resulting from point mutations or chimaeric fusion genes, such as BCR ABL1 or JAK2 V617F. We report here for the first time in hematological malignancies, two novel fusion genes involving ...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-34900 | biostudies-arrayexpress
UnknownTwo distinct fetal-type signatures characterize juvenile myelomonocytic leukemia.
Not available
S-EPMC11934893 | biostudies-literature
TranscriptomicsJuvenile Myelo Monocytic Leukemia (JMML) genetic screaning (tumor versus fibroblasts)
Dectection of somatic copy number variations from Affymetrix 6.0 SNP array
ORGANISM(S): Homo sapiens 
2015-07-31 | E-MTAB-3729 | biostudies-arrayexpress
UnknownJuvenile myelomonocytic leukemia stem cells are sensitive to NK cell-mediated lysis and express targetable antigens.
Not available
S-EPMC12711676 | biostudies-literature
UnknownPhenotypic profiling of CD34+ cells by advanced flow cytometry improves diagnosis of juvenile myelomonocytic leukemia.
Not available
S-EPMC10828789 | biostudies-literature
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