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ProteomicsT he proteostasis interactomes of trafficking - deficient K V 11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue
The voltage gated potassium ion channel KV11.1 plays a critical role in cardiac repolarization. Genetic variants that render Kv11.1 dysfunctional cause Long QT Syndrome (LQTS), which is associated with fatal arrhythmias. Approximately 90% of LQTS-associated variants cause intracellular protein trans...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050914 | Pride
Herg Long qt syndrome Ion channel Trafficking K v 11.1 Interactome 
UnknownIn silico analysis of the dynamic regulation of cardiac electrophysiology by Kv 11.1 ion-channel trafficking.
Not available
S-EPMC10313819 | biostudies-literature
UnknownInverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643.
Not available
S-EPMC5797642 | biostudies-literature
UnknownCelebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels Kv 7.1 and Kv 11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes.
Not available
S-EPMC9286829 | biostudies-literature
UnknownLoss-of-function variants in Kv 11.1 cardiac channels as a biomarker for SUDEP.
Not available
S-EPMC8283159 | biostudies-literature
TranscriptomicsHepG2 treated with two Polycyclic Aromatic Hydrocarbons (benzo[a]anthracene & benzo[k]fluoranthene)
To gain deeper insight into the mechanism of toxicity, it is important to identify and characterize miRNAs profiles involved in responses to specific classes of toxicants in conjunction with their impact on gene expression levels. However, few reports have described the effects of toxicants on miRNA...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-49068 | biostudies-arrayexpress
UnknownThe combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells.
Not available
S-EPMC5785745 | biostudies-literature
UnknownA need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1.
Not available
S-EPMC9968853 | biostudies-literature
UnknownInhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction.
Not available
S-EPMC7219273 | biostudies-literature
UnknownLUF7244, an allosteric modulator/activator of K<sub>v</sub> 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
Not available
S-EPMC6780032 | biostudies-literature
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