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TranscriptomicsRNA-seq of hiPSC-ECs from HNF1A-MODY patient and corrected isogenic control lines
The experiment aims to find differences in gene expression in endothelial cells due to a heterozygous mutation in HNF1A, which cause maturity-onset diabetes of the young (MODY). For that purpose human induced pluripotent stem cell (hiPSCs) line from an HNF1A-MODY patient was repaired using CRISPR/Ca...
ORGANISM(S): Homo sapiens 
2026-02-22 | E-MTAB-16548 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of sarcoidosis Treg cells
Sarcoidosis is characterized by exaggerated immune response to unknown agent and can affect different organs. One of the main players in the pathology of the disease are regulatory T cells (Tregs), however up to date there are no insides on the possible molecular alterations of this particular cell ...
ORGANISM(S): Homo sapiens 
2018-09-29 | E-MTAB-6590 | biostudies-arrayexpress
ProteomicsChanges in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene
Maturity onset diabetes of the young (MODY) is caused by a mutation in a single gene and leads to diabetes under the age of 25. The mutations in HNF1A gene (leading to HNF1A-MODY) cause about 70% of all MODY cases. It was shown that patients with HNF1A-MODY often develop diabetic microvascular compl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-01 | PXD039471 | Pride
Maturity onset diabetes of the young Endothelial cells Hnf1a-mody Ipscs-ec 
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