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ProteomicsThe effect of interferons on presentation of defective ribosome products as HLA peptides
The class I major histocompatibility complex (MHC) bound peptides, produced from immature proteins that are degraded rapidly are called defective ribosome products (DRiPs). Such DRiPs are possibly involved with early alerting of the immune system about impeding infections, thus bringing about faster...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD022633 | Pride
Hla peptides Mhc Ifns Drips 
ProteomicsMHC peptides presentation is limited by availability of empty HLA molecules rather than the supply of peptides ligands
Whether the presentation levels of the major histocompatibility complex (MHC, called the human leukocytes antigens, HLA, in humans) is limited by the availability of peptide ligands for loading or by the supply of empty MHC molecules, is a yet unresolved issue. This study aims to tackle this dilemma...
ORGANISM(S): Homo sapiens (Human) 
2018-05-10 | PXD007596 | Pride
Interferon Mhc Peptidome Immunopeptidome Hla 
ProteomicsThe effect of interferons on presentation of defective ribosome products as HLA peptides
The class I major histocompatibility complex (MHC) bound peptides, produced from immature proteins that are degraded rapidly are called defective ribosome products (DRiPs). Such DRiPs are possibly involved with early alerting of the immune system about impeding infections, thus bringing about faster...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-25 | MSV000096209 | MassIVE
Proteomics,MultiomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080843 | MassIVE
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
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