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ProteomicsCSF proteomics of the APPPS1 Alzheimer mouse model with life long BACE inhibition
The earliest defining event in the pathogenesis of Alzheimer´s disease (AD) is the intracerebral deposition of Abeta, which starts at least 20 years before the onset of dementia. The link between Abeta and downstream neurodegeneration leading to dementia remains unclear, a critical gap in knowledge ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD032782 | Pride
Cerebrospinal fluid Bace Alzheimer disease Appps1 Csf 
ProteomicsCerebrospinal Fluid (CSF) Proteomics of APPPS1 mice
Here, we took advantage of well-defined mouse models for β-amyloidosis (APPPS1) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo a...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-21 | PXD021322 | Pride
Mouse Appps1 Alzheimer Amyloid beta 
ProteomicsCerebrospinal Fluid (CSF) Proteomics of A30P-αS mice
Here, we took advantage of well-defined mouse models for α-synucleinopathy (A30P-αS ) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that unde...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-21 | PXD021356 | Pride
Parkinson's disease Cerebrospinal fluid Csf 
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