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TranscriptomicssnATAC-seq of the developing mouse cerebellum across eleven stages
This study used droplet-based snATAC-seq to profile the chromatin accessibility landscape of 91,922 nuclei in the mouse cerebellum across eleven developmental stages, from the beginning of neurogenesis (e10.5) till adulthood (P63). The study included two biological replicates per stage, one from eac...
ORGANISM(S): Mus musculus 
2021-09-07 | E-MTAB-9765 | biostudies-arrayexpress
TranscriptomicssnATAC-seq of the gray short-tailed opossum cerebellum in two developmental stages
This study used droplet-based snATAC-seq to profile the chromatin accessibility landscape of 19,204 nuclei in the opossum (Monodelphis domestical) cerebellum across two developmental stages (postnatal day 21 and adult). The study included two biological replicates per stage, one from each sex, and a...
ORGANISM(S): Monodelphis domestica 
2021-09-07 | E-MTAB-10533 | biostudies-arrayexpress
TranscriptomicsPlatypus fibroblast and ovary transcriptomes
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore dosage balance between the X and autosomes, and that the resulting X ...
ORGANISM(S): Ornithorhynchus anatinus 
2012-05-16 | E-GEOD-36120 | biostudies-arrayexpress
TranscriptomicsEvolution of mammalian miRNA genes
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data. Using RNA sequencing, we have generated extensive and comparable miRNA data for five organs...
ORGANISM(S): Macaca mulatta 
2012-10-01 | E-GEOD-40499 | biostudies-arrayexpress
TranscriptomicsThe evolution of lncRNA repertoires and expression patterns in tetrapods
Only a minuscule fraction of long non-coding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but comparative analyses have been precluded by our ignorance of lncRNAs in non-model organisms. Here, we use RNA sequencing to ident...
ORGANISM(S): Ornithorhynchus anatinus 
2014-01-19 | E-GEOD-43520 | biostudies-arrayexpress
TranscriptomicsUsing ribosome profiling and matched RNA sequencing to study the co-evolution of transcriptome and translatome in mammalian organs
Ribosome profiling (Ribo-seq) and matched RNA sequencing (RNA-seq) data for three major mammalian organs (brain (cerebrum), liver, and testis) from five representatives of the three main mammalian lineages: human, rhesus macaque, mouse (placental mammals); grey short-tailed opossum (marsupials); and...
ORGANISM(S): Mus musculus 
2020-07-23 | E-MTAB-7247 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq cells)
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome€wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular sources, transcriptional mechanisms, and func...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43717 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq organs)
Understanding  the  extent  of  genomic  transcription  and  its  functional  relevance  is  a  central  goal  in  genomics research. However, detailed genome‐wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular  sources,  transcriptional  mec...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43721 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Monodelphis domestica to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to gray short-tailed opossum RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcript...
ORGANISM(S): Monodelphis domestica 
2011-10-12 | E-MTAB-3719 | biostudies-arrayexpress
TranscriptomicsRNA-seq of 6 tissues from Homo sapiens to investigate the evolution of gene expression levels in mammalian organs
This experiment contains the subset of data corresponding to human RNA-Seq data from experiment E-GEOD-30352 (http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-30352/), which goal is to understand the dynamics of mammalian transcriptome evolution. To study mammalian transcriptome evolution at hig...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-MTAB-3716 | biostudies-arrayexpress
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