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Absence of the epigenetic regulator Kaiso suppresses Wnt driven intestinal tumourigenesis. To identify genes regulated by Kaiso we generated wild type and Kaiso-/- mice for microarray expression analysis to identify genes derepressed in the absence of Kaiso.
ORGANISM(S): Mus musculus 
Kaiso Mediates Transcription and RNA splicing in Colorectal Carcinoma: Role of BRCA1 in the Kaiso Enhanceosome
Kaiso, a critical regulator of spermatogenesis
Kaiso (ZBTB33) is a transcription factor involved in mitotic clonal expansion and tumorigenesis in association with APC loss of heterozygosity. ENCODE data show strong overlap of the Kaiso promoter binding cite (eKBS) and many other transcription factors, including BRCA1. Here we sought to determine...
ORGANISM(S): Homo sapiens 
2025-06-16 | GSE294265 | GEO
Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma
The Hippo pathway effectors yes associated protein (YAP) and transcriptional co activator with PDZ binding motif (TAZ) are key regulators of hepatic stellate cell (HSC) activation and liver fibrosis. While the canonical YAP/TAZ–TEAD transcriptional axis has been extensively characterized, non canoni...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD074737 | Pride
Spermatogenesis is a highly coordinated process by which diploid spermatogonia (2n) differentiate into mature haploid (1n) spermatozoa in the seminiferous epithelium. Here, we show that Kaiso (Zbtb33) is critical to spermatogenesis, via binding to KBEs (Kaiso-binding elements) in the 5’ upstream reg...
ORGANISM(S): Mus musculus 
2021-03-05 | GSE111409 | GEO
Kaiso engages with non-canonical binding motifs to regulate DNA damage responses in breast cancer
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