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ProteomicsMouse adipocyte phosphoproteome during differentiation
Kosaku Shinoda, Kana Ohyama, Yutaka Hasegawa, Hsin-Yi Chang, David W. Scheel, Louis Z. Sharp, Haemin Hong, Takashi Hosono, Mayu Ogura, Ayaka Sato, Yasushi Ishihama, and Shingo Kajimura. Phosphoproteomics Identifies CK2 As a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-08-28 | MSV000079278 | MassIVE
TranscriptomicsExpression data from C2C12 myoblasts transduced with PRDM16 or vector
PRDM16 is a 140 kDa transcriptional coregulatory protein. PRDM16 has been shown to function as a bi-directional switch in brown fat cell fate by stimulating the development of brown fat cells from myf-5 positive myoblastic precursors. We used microarrays to detail the global programme of gene expres...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15895 | biostudies-arrayexpress
ProteomicsUncoupling Metabolic Health from Thermogenesis via BCAA Flux in Brown Fat
Brown adipose tissue (BAT) is best known for thermogenesis. Whereas numerous studies in rodents found tight associations between the metabolic benefits of BAT and enhanced whole-body energy expenditure, emerging evidence in humans suggests that BAT is protective against Type 2 diabetes independent o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-15 | PXD043992 | Pride
Brown adipose tissue (bat) Branched-chain amino acids (bcaa) 
ProteomicsUncoupling Metabolic Health from Thermogenesis via BCAA Flux in Brown Fat
Brown adipose tissue (BAT) is best known for thermogenesis. Whereas numerous studies in rodents found tight associations between the metabolic benefits of BAT and enhanced whole-body energy expenditure, emerging evidence in humans suggests that BAT is protective against Type 2 diabetes independent o...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-15 | PXD044020 | Pride
Brown adipose tissue (bat) Branched-chain amino acids (bcaa) 
ProteomicsThermogenic role of C4orf3/ALN in adipose tissue
Introduction: Adipose tissue is a complex endocrine organ and active participant in the initiation and progression of metabolic disorders such as obesity and diabetes. While often overlooked, calcium uptake and cycling in the endoplasmic reticulum (ER) are known to play key roles in glucose homeosta...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD059431 | Pride
Adipose Thermogenesis Microsomes 
TranscriptomicsTranscription profiling of mouse brown versus white tissue adipose
The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Experiment Overall Design: Interscapular brown adipose tissue and epididy...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8044 | biostudies-arrayexpress
TranscriptomicsPPARg agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; however, the underlying mechanisms remain unclear. Here we show that PPARγ ligands require full agonism to induce a brown...
ORGANISM(S): Mus musculus 
2012-03-06 | E-GEOD-35011 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of supraclavicular and subcutaneous abdominal adipose tissue samples collected during CE (cold exposure) and TN (thermoneutral) conditions
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. To gain insight regarding the mechanisms of accelerated lipid metabolism in relation to the cold-a...
ORGANISM(S): Homo sapiens 
2016-05-26 | E-MTAB-4031 | biostudies-arrayexpress
ProteomicsBeta-cell Galphas signaling is critical for physiological and pharmacological enhancement of insulin secretion
Islet lysates were adjusted to 5 percent SDS in TEAB, pH 8.5, reduced and alkylated and digested with modified trypsin (Worthington) using an S-trap mini device (Protifi). Peptides were labeled with TMT16 reagents (lot ZH350094). Phosphopeptide enrichment used GL Sciences p10 TiO tips. LC-MS/MS used...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-05-13 | MSV000097882 | MassIVE
ProteomicsSortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation; however, the regulatory mechanism of the subcellular...
ORGANISM(S): Mus Musculus 
PXD055014 |
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