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ProteomicsHDAC3 preferentially binds to RUNX1 in t(8;21) AML cells and collaborates with RUNX1 to repress AML1-ETO-mediated transcriptional activation
Human histone deacetylase 3 (HDAC3) plays an important role in gene transcription in diseased human cells, such as leukemia. The t(8;21) chromosomal translocation is one of the most commonly observed genetic abnormalities associated with acute myeloid leukemia. This translocation generates the AML1-...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD017230 | Pride
Aml Runx1 Leukemia Hdac3 T(8 21) translocation 
ProteomicsThe Plethora of Angiotensin-Converting Enzyme Substrates in Mouse Plasma
Angiotensin converting enzyme (ACE) is known for converting inactive angiotensin I into the potent vasoconstrictor angiotensin II, playing a critical role in blood pressure regulation. However, there is evidence that the dicarboxypeptidase activity of ACE is also essential for other physiological pr...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010258 | Pride
Peptidomics 
ProteomicsPeptidomic Analysis of Natural Substrates of the Promiscuous Angiotensin-Converting Enzyme
In the current study we exploit this technical advantage to maximize discovery of possible substrates and products of ACE present in plasma
ORGANISM(S): Mus musculus (Mouse) 
2022-03-02 | PXD009611 | Pride
Peptidomics 
ProteomicsProteome and secretome profiling of Knufia chersonesos MA5789 wt and MA5790 mutant exposed to low sheer simulated microgravity (LSSMG)
Proteome and secretome of the extremotolerant rock black fungus Knufia chersonesos and its nonmelanized spontaneous mutant were analyzed following the fungus growth under LSSMG in rotating bioreactors (High Aspect Ratio Vessels; HARV). Tandem Mass Tags (TMS)-based quantitative shotgun proteomics was...
ORGANISM(S): Knufia petricola 
2021-05-31 | PXD022898 | Pride
Knufia chersonesos  simulated microgravity  tmt proteomics 
ProteomicsProteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station
The on-going Microbial Observatory Experiments on the International Space Station (ISS) revealed the presence of various microorganisms that may be affected by the distinct environment of the ISS. The low-nutrient environment combined with enhanced irradiation and microgravity may trigger changes in...
ORGANISM(S): Aspergillus fumigatus Af293 
2019-01-09 | PXD008517 | Pride
Aspergillus fumigatus Proteomic International space station 
ProteomicsGenomic and Proteomic characterization of Aspergillus niger isolated from the International Space Station
Genomic and proteomic characterization of the Aspergillus niger isolate, JSC-093350089, collected from U.S. segment surfaces of the International Space Station (ISS) is reported, along with a comparison to the experimentally established strain ATCC 1015. Whole-genome sequencing of JSC-093350089 reve...
ORGANISM(S): Aspergillus niger 
2018-08-21 | PXD008588 | Pride
Proteomic Aspergillus niger International space station 
ProteomicsAlteration of Proteomes in First-generation Cultures of Bacillus pumilus Spores Exposed to Outer Space
Bacillus pumilus SAFR-032 was originally isolated from the Jet Propulsion Lab Spacecraft Assembly Facility and thoroughly characterized for its enhanced resistance to UV irradiation and oxidative stress. This unusual resistance of SAFR-032 is of particular concern in the context of planetary protect...
ORGANISM(S): Bacillus pumilus (strain SAFR-032) 
2019-05-21 | PXD011292 | Pride
Space conditions Tandem mass tag Proteomics Uv resistance Bacillus pumilus safr-032 Mars atmosphere 
ProteomicsInfluence of International Space Station Conditions on Fungal ‘Omics’ in Aspergillus nidulans
This study presents the first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus, Aspergillus nidulans, following growth on the International Space Station (ISS). The investigation included the A. nidulans wild-type and 3 mutant strains, two of which were...
ORGANISM(S): Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 
2022-05-19 | PXD010778 | Pride
Aspergillus nidulans International space station Omics 
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