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ProteomicsLocal GTP availability is an essential step in regulation of RAC1 activity and cell invasion
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because GTP concentrations determined by chromatography or mass spectrometry were shown to be substantially higher than the RAC1 GTP dissociation constant (RAC1-GTP Kd) determined in vit...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028540 | Pride
Gtp sensors Impdh2 Rac1 Gtp 
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
UnknownRegulation of local GTP availability controls RAC1 activity and cell invasion.
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