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Proteomicsp-FADD-CD8+T cell axis determines hepatocellular carcinoma response to immune checkpoint inhibitors
The heterogenicity of hepatocellular carcinoma (HCC) remains a key obstacle in turning the majority of ‘immune-cold’ tumors ‘hot’ for effective immune checkpoint inhibitors (ICIs). Through analyzing the naturally-existed ‘hot’ HCC variants, we identified fas-associated death domain (FADD) as a key m...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD057519 | Pride
Hcc Fadd Hepg2 
UnknownIL6/adiponectin/HMGB1 feedback loop mediates adipocyte and macrophage crosstalk and M2 polarization after myocardial infarction.
Not available
S-EPMC11004445 | biostudies-literature
TranscriptomicsGATA factors efficiently direct cardiac fate from ESCs
Gata5 efficiently promotes cardiomyocyte fate from murine ESCs.By removing serum from the culture conditions, GATA4 and GATA6 are each also able to efficiently promote cardiogenesis in ESC derivatives, with some distinctions. Thus, GATA factors can function in ESC derivatives upstream of other car...
ORGANISM(S): Mus musculus 
2013-02-02 | E-GEOD-43831 | biostudies-arrayexpress
GenomicsGenome-wide analysis of ETS factor ER71/ETV2 chromatin occupancy
We discover that ER71/ETV2 initiates hemangiogenic program by activating blood and endothelial cell lineage specifying genes while enhancing FLK1 expression and expanding hemangioblast population. Furthermore, ER71/ETV2 establishes an ETS hierarchy by directly activating Ets genes in hematopoietic a...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-59402 | biostudies-arrayexpress
UnknownMutations in pseudohypoparathyroidism 1a and pseudopseudohypoparathyroidism in ethnic Chinese.
Not available
S-EPMC3961212 | biostudies-literature
ProteomicsPARP1-SNAI2 Transcription Axis Drives Resistance to PARP Inhibitor, Talazoparib
The synthetic lethal association between BRCA deficiency and poly (ADP-ribose) polymerase (PARP) inhibition supports PARP inhibitor (PARPi) clinical efficacy in BRCA-mutated tumors. PARPis also demonstrate activity in non-BRCA mutated tumors presumably through induction of PARP1-DNA trapping. Despit...
ORGANISM(S): Homo sapiens (Human) 
2022-07-08 | PXD033530 | Pride
Parp1 Drug resistance Talazoparib 
UnknownGenomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients.
Not available
S-EPMC6814827 | biostudies-literature
TranscriptomicsEarly Events in Hematopoietic Cells Reprogramming into iPS Cells
Fibroblasts are the most commonly used model in probing the complex process of somatic reprogramming. Although hematopoietic cells represents a more  convenient and accesible/ or “an excellent alternative” starting cell type, the molecular mechanisms in hematopoietic reprogramming are poorly defined...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-54462 | biostudies-arrayexpress
TranscriptomicsMolecular effects of different TRPV3 Mutations
To understand the impact of dysfunctional TRPV3 on keratinocyte proliferation and differentiation, we conducted transcriptomic analysis on cells that express cloned different TRPV3 mutations identified in focal palmoplantar keratoderma (FPPK) patients and identified a number of perturbed pathways as...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-71236 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis of the brain and colon in three rat models of irritable bowel syndrome
Background: Irritable bowel syndrome (IBS) has been gradually recognized as a disorder of the brain-gut interaction, but the molecular changes in the brain and colon that occur in disease development remain poorly understood. We employed proteomic analysis to identify differentially expressed protei...
ORGANISM(S): Rattus Rattus 
2020-01-15 | PXD017099 |
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