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UnknownExpression of endogenous retroviral elements is associated with extracellular matrix remodeling in prostate cancer.
Not available
S-EPMC12781564 | biostudies-literature
TranscriptomicsRNA-Seq analysis of Trim28-deleted NPp53 mouse prostate tissue
Tripartite motif-containing 28 (TRIM28/TIF1b/KAP1) is a key transcriptional co-repressor protein that represses ERV expression in many cell types including embryonic stem cells, neural progenitor cells, differentiated adult cells, and cancer cells. In this study, we investigated the effect of Trim28...
ORGANISM(S): Mus musculus 
2026-01-08 | GSE298402 | GEO
GenomicsHomo sapiens
ChIP-seq of TIF1b modulates the chromatin accessibility to regulate the self-renewal and differentiation of leukemic stem cells
PRJDB14732 | ENA
GenomicsMus musculus
RNA-seq of TIF1 modulates the chromatin accessibility to regulate the self-renewal and differentiation of leukemic stem cells
PRJDB14731 | ENA
GenomicsMus musculus
ATAC-seq of TIF1b modulates the chromatin accessibility to regulate the self-renewal and differentiation of leukemic stem cells
PRJDB14733 | ENA
GenomicsRNA-Seq analysis of Trim28-deleted NPp53 mouse prostate tissue
RNA-Seq analysis of Trim28-deleted NPp53 mouse prostate tissue
PRJNA1269089 | ENA
ProteomicsPML Nuclear Bodies are stress-responsive sumoylation/degradation compartments regulating KAP1 silencing function in embryonic stem cells
PML drives the assembly of PML Nuclear Bodies (NBs), where it recruits many serendipitously-identified proteins, including the SUMO-E2 enzyme UBC9. Interferons, arsenic or oxidative stress, all enhance NB-formation. Here demonstrate that PML is required for efficient basal sumoylation in mouse embry...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-14 | PXD019609 | Pride
Transposable elements Embryonic stem cells Stress Dppa2 Pml nuclear bodies Arsenic Sumoylation Ubiquitin Acute promyelocytic leukemia Kap1-trim28-tif1b 
GenomicsTRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
TRIM28 (KAP1 - KRAB-associated protein 1) is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators c...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-41903 | biostudies-arrayexpress
TranscriptomicsRNA-seq of ZFP30 knock-down and knock-out in mouse 3T3-L1 and IBA cells during adipogenic differentiation
We show that a hitherto poorly characterized KRAB domain-containing zinc-finger (ZF) transcription factor, ZFP30, positively regulates adipogenesis. We demonstrate ZFP30’s function in murine in vitro and in vivo models, as well as in human stromal vascular fraction cells. We reveal through mechanist...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6995 | biostudies-arrayexpress
GenomicsChIP-seq of ZFP30-HA and KAP1 in mouse 3T3-L1 cells during adipogenic differentiation
We show that a hitherto poorly characterized KRAB domain-containing zinc-finger (ZF) transcription factor, ZFP30, positively regulates adipogenesis. We demonstrate ZFP30’s function in murine in vitro and in vivo models, as well as in human stromal vascular fraction cells. We reveal through mechanist...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6817 | biostudies-arrayexpress
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