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ProteomicsDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate the emergence of 2C-like cells and zygotic transcriptional program
The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals remains poorly understood. The 2C-like cells spontaneously emerging from cultures of mouse embryonic stem cells (ESCs) share some key transcriptional and epigenetic programs with 2-cell stage embryos. By studying the ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-06 | PXD012925 | Pride
Pias4 dppa2 zga sumoylation 
TranscriptomicsRole of ECAT15-2/Dppa2 in lung development
This SuperSeries is composed of the following subset Series: GSE31581: ECAT15-2/Dppa2 deficient ESCs GSE31582: ECAT15-2/Dppa2 transgenic rescue into ECAT15-2/Dppa2 deficient ESCs GSE31583: Lung of ECAT15-2/Dppa2 deficient embryo at E18.5 Refer to individual Series
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-31584 | biostudies-arrayexpress
ProteomicsHuman non-small cell lung cancer cell line NCI-H661 DPPA2-4 rapid immunoprecipitation mass spectrometry (RIME, LC-MSMS)
To investigate DPPA2/4 bound proteins on chromatin we performed rapid immunoprecipitation mass spectrometry (RIME) following double crosslinking of chromatin in NCI-H661 non-small cell lung cancer cells clonal cell lines (Wild Type clones c51 & c52, DPPA2 knockout clones c41 & c42, DPPA4 knockout cl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD070627 | Pride
Rime Dppa4 Non small cell lung cancer Ncih661 Dppa2 Human 
ProteomicsHuman non-small cell lung cancer cell line NCI-H661 DPPA2-4 immunoprecipitation mass spectrometry (LC-MSMS)
We performed endogenous DPPA2/4 immunoprecipitations from whole cell lysates of the human non-small cell lung cancer cell line NCI-H661, followed by LC-MS/MS to identify enriched proteins.
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD070581 | Pride
Lung Dppa4 Nci-h661 Immunoprecipitation Dppa2 Human 
TranscriptomicsECAT15-2/Dppa2 transgenic rescue into ECAT15-2/Dppa2 deficient ESCs
Many transcription factors and DNA binding proteins play essential roles in the development of organs in which they are highly and/or specifically expressed. Embryonic stem cell (ESC) associated transcript (ECAT) 15-1 and ECAT15-2, also known as developmental pluripotency-associated (Dppa) 4 and Dpp...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-31582 | biostudies-arrayexpress
TranscriptomicsECAT15-2/Dppa2 deficient ESCs
Many transcription factors and DNA binding proteins play essential roles in the development of organs in which they are highly and/or specifically expressed. Embryonic stem cell (ESC) associated transcript (ECAT) 15-1 and ECAT15-2, also known as developmental pluripotency-associated (Dppa) 4 and Dpp...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-31581 | biostudies-arrayexpress
ProteomicsDppa2/4 target chromatin bivalency enabling multi-lineage commitment
Epigenetic priming factors establish a permissive epigenetic landscape which is not required until a later developmental or physiological time point, temporally uncoupling the presence of these factors with their phenotypic effects. One classic example of epigenetic priming is in the context of biva...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD014981 | Pride
Qplex rime Epigenetic priming Compass Bivalency Development Trithorax 
TranscriptomicsLung of ECAT15-2/Dppa2 deficient embryo at E18.5
Many transcription factors and DNA binding proteins play essential roles in the development of organs in which they are highly and/or specifically expressed. Embryonic stem cell (ESC) associated transcript (ECAT) 15-1 and ECAT15-2, also known as developmental pluripotency-associated (Dppa) 4 and Dpp...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-31583 | biostudies-arrayexpress
UnknownDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program.
Not available
S-EPMC6608977 | biostudies-literature
UnknownDppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program.
Not available
S-EPMC6362816 | biostudies-literature
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