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ProteomicsShiga toxin-positive extracellular vesicles induce higher mortality and more kidney injury than free toxin
Escherichia coli O157:H7 is a non-invasive Shiga toxin (Stx)-producing pathogen that causes gastroenteritis and hemolytic uremic syndrome characterized by acute kidney injury. Stx binding to cells induces release of extracellular vesicles (EVs) containing the toxin. This study aimed to demonstrate t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD065687 | Pride
Globotriaosylceramide Shiga toxin 2 Extracellular vesicles 
ProteomicsAngiotensinogen and C3 compete for renin-induced complement activation
Demonstration of renin cleavage of C3. Angiotensinogen and C3 compete for renin-induced complement activation.
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD053116 | Pride
C3 Renin Angiotensinogen Lc-ms/ms 
ProteomicsIgG binds Escherichia coli serine protease EspP and protects mice from E. coli O157:H7 infection
The effect of pooled immunoglobulins (IgG) on E. coli O157:H7 colonization and the course of disease in an EHEC mouse model was investigated showing an improved survival and decreased intestinal and renal pathology. Treatment was given after inoculation thereby corresponding to the clinical setting....
ORGANISM(S): Escherichia coli 
2022-02-08 | PXD029563 | Pride
Hemolytic uremic syndrome Shiga toxin Espp Mouse Escherichia coli o157:h7 Immunoglobulin g 
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