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TranscriptomicsscRNAseq libraries of pooled kidney samples from wild type (ZF1) versus CRISPR-targeted renin knockout (ZF2) zebrafish
Libraries were made to compare the transcriptome of renin lineage cells (RLCs) from wild-type versus ren knockout zebrafish kidneys. RLCs were FAC sorted from pooled kidneys of ren+/+ or ren-/- zebrafish, which carried ren:RFP and acta2:EGFP reporter genes, allowing the isolation of renin-expressin...
ORGANISM(S): Danio rerio 
2022-06-10 | E-MTAB-11079 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse bone marrow cells expressing renin driven expression of green fluorescent protein.
Local renin antiotensin systems have been identified for many extra-renal sites. Bone marrow has been proposed as one such site, although the nature of the renin-expressing cell type(s) has not been established. Affymetrix microarrays were used to characterize the expression profile of renin-express...
ORGANISM(S): Mus musculus 
2014-02-17 | E-GEOD-53916 | biostudies-arrayexpress
TranscriptomicsMouse kidney arteriolar smooth muscle cells derived from the renin cell lineage: control vs. forskolin treatment to induce renin expression
miRNA profiling of mouse kidney arteriolar smooth muscle cells (aSMCs) of the renin lineage comparing control untreated cells with cells treated with forskolin to induce renin expression. Two condition experiment: control untreated aSMCs vs forskolin treated aSMCs; Biological replicates: control 3, ...
ORGANISM(S): Mus musculus 
2012-02-25 | E-GEOD-31780 | biostudies-arrayexpress
ProteomicsAngiotensinogen and C3 compete for renin-induced complement activation
Demonstration of renin cleavage of C3. Angiotensinogen and C3 compete for renin-induced complement activation.
ORGANISM(S): Homo sapiens (Human) 
2025-04-18 | PXD053116 | Pride
C3 Renin Angiotensinogen Lc-ms/ms 
TranscriptomicsGene expression profiles of the renin producing cells in the kidney (GUDMAP Series_id: 29)
The long term objective is to create an encyclopedia of the expression levels of all genes in multiple components of the developing kidney. The central thesis is straightforward. The combination of fluorescent activated cell sorting (FACS) plus microarray analysis offers a powerful, efficient and e...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-17138 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adipose tissue, decidua and placenta from patients with preeclampsia vs. unaffected indviduals reveals dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
Preeclampsia complicates more than 3% of all pregnancies in the United States and Europe. High-risk populations include women with diabetes, dyslipidemia, thrombotic disorders, hyperhomocysteinemia, hypertension, renal diseases, previous preeclampsia, twin pregnancies, and low socioeconomic status. ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6573 | biostudies-arrayexpress
ProteomicsKSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
ORGANISM(S): Homo Sapiens (human) 
2020-12-15 | PXD010107 | JPOST Repository
TranscriptomicsNew role for the (pro)renin receptor in T cell development
The (pro)renin receptor (PRR) was originally thought to be important in regulating blood pressure via the renin-angiotensin system (RAS), however it is emerging that PRR is instead generally essential for cellular development via its involvement in Wnt signalling. Here, we have specifically deleted ...
ORGANISM(S): Mus musculus 
2015-07-01 | E-MTAB-3568 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse kidney tissue
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagoni...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-34552 | biostudies-arrayexpress
GenomicsMouse spleen: Histone modification patterns in spleens from wild type and leukemic mice
ChIP-Seq for H3K4me3 and H3K27me3 in wild type spleens and spleens from mice having deletion of RBP-J in cells of the renin lineage, which results in B-cell leukemia. Examination of 2 different histone modifications in wild type and mutant spleens.
ORGANISM(S): Mus musculus 
2014-02-17 | E-GEOD-46566 | biostudies-arrayexpress
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