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TranscriptomicsA mutation of RNA polymerase β’ subunit (RpoC) converts heterogeneously vancomycin-intermediate S. aureus (hVISA) into ‘slow-VISA’ (sVISA)
Various mutations in the rpoB gene, which encodes the RNA polymerase beta subunit, are associated with increased vancomycin (VAN) resistance in vancomycin-intermediate S. aureus (VISA) and hetero-VISA (hVISA) strains. We reported that rpoB mutations are also linked to the expression of the recently ...
ORGANISM(S): Staphylococcus aureus 
2015-05-08 | E-GEOD-65338 | biostudies-arrayexpress
TranscriptomicsA Single Amino-Acid Substitution of RNA Polymerase M-CM-^_ subunit Confers A Novel Class of VISA phenotype on hVISA Strain Mu3
hVISA clinical strain Mu3 spontaneously generates VISA at an extremely high frequency (1x10-6 or greater) within its cell population. The VISA-converted mutant strains generally grow slower than their parent hVISA strain, but they usually form colonies on vancomycin-containing agar plates after 48 h...
ORGANISM(S): Staphylococcus aureus 
2014-03-31 | E-GEOD-50826 | biostudies-arrayexpress
TranscriptomicsMutation of the RNA polymerase M-NM-2-subunit gene promotes hetero-to-homo conversion of M-CM-^_-lactam resistance of methicillin-resistant Staphylococcus aureus
Three types of phenotypic expression of M-CM-^_-lactam resistance has been reported in MRSA: heterogeneous-, homogeneous-, and Eagle-type resistance. Heterogeneous to homogeneous (hetero-to-homo) conversion of M-CM-^_-lactam resistance is postulated to be caused by a chromosomal mutation (chr*) toge...
ORGANISM(S): Staphylococcus aureus 
2013-08-27 | E-GEOD-42218 | biostudies-arrayexpress
UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Not available
S-EPMC12339405 | biostudies-literature
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Not available
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Not available
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Not available
S-EPMC12553428 | biostudies-literature
UnknownSafety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: The OCEAN-Mitral Registry.
Not available
S-EPMC12826929 | biostudies-literature
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