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UnknownA Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.
BACKGROUND:Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and ...
S-EPMC6777093 | biostudies-literature
UnknownApathy, depression, and dementia risk in older adults: A global collaborative study.

Introduction

The role of apathy in predicting dementia risk, especially with coexisting depression, remains unclear in community-dwelling older adults.

Methods

We analyzed data from 12,646 older adults without baseline dementia across ten population-based cohorts from six continents (...
S-EPMC12746046 | biostudies-literature
UnknownAPOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.
We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studie...
S-EPMC7518559 | biostudies-literature
UnknownGenetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Background

The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differentia...
S-EPMC8059115 | biostudies-literature
UnknownRisk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Background

The genetic risk factors for susceptibility to chronic obstructive pulmonary disease (COPD) are still largely unknown. Additional genetic variants are likely to be identified by genome-wide association studies in larger cohorts or specific subgroups. We sought to identify risk loc...
S-EPMC4176924 | biostudies-literature
UnknownWhole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.

Background

Plasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on individuals of European descent and leveraged genotyping arrays an...
S-EPMC9158509 | biostudies-literature
UnknownWhole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, t...
S-EPMC9395431 | biostudies-literature
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