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TranscriptomicsComparative transcriptional profiling of the lung discriminates S. pneumoniae and Influenza A Virus infections
Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated b...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-5289 | biostudies-arrayexpress
GenomicsCharacterization of SOC1’s central role in flowering by the identification of its upstream and downstream regulators
The transition from vegetative to reproductive development is one of the most important phase changes in the plant life cycle. This step is controlled by various environmental signals that are integrated at the molecular level by so-called floral integrators. One such floral integrator in Arabidopsi...
ORGANISM(S): Arabidopsis thaliana 
2013-04-09 | E-GEOD-45846 | biostudies-arrayexpress
TranscriptomicsSubunit-specific vs. non-selective proteasome modulation in limiting inflammation in experimental colitis
Inflammatory bowel disease (IBD), comprising CrohnM-BM-4s disease and Ulcerative colitis, is characterized by chronic relapsing inflammation of the gut. It has been shown that increased proteasomal activity is associated with the expression of immunoproteasomes, which enhances NF-kB activation and t...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18163 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MH-S cell line with methylglyoxal induces apoptosis and immune response
Mycobacteria-induced apoptosis of macrophages plays an important role in modulation of the host immune response involving TNF-alpha as major cytokine. The underlying mechanisms are still ill-defined. Here, we show for the first time that methylglyoxal (MG) and AGEs levels were elevated during mycoba...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3837 | biostudies-arrayexpress
TranscriptomicsMicroRNA miR-223 constrains lethal inflammation during Mycobacterium tuberculosis infection
The molecular mechanisms that control innate cell recruitment during chronic infection and inflammation, such as tuberculosis (TB), are incompletely understood. During TB, myeloid cells infiltrate the lung and sustain local inflammation. We identified microRNA (miR)-223 as one of the most abundant n...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-39163 | biostudies-arrayexpress
TranscriptomicsTB disease classification
Validation of gene expression levels to assess classification of TB patients and healthy controls qPCR gene expression profiling. Whole blood gene expression from TB patients (positive in GenXpert assay) and healthy controls; both tuberculin skin test positive (TSTpos) and -negative (TSTneg).
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-74092 | biostudies-arrayexpress
TranscriptomicsLung-resident myeloid-derived suppressor cells display dual functionality in experimental tuberculosis
Using cell-based approaches and experimental mouse models for pulmonary TB we unveiled MDSCs as new myeloid populations directly interacting with Mycobacterium tuberculosis (Mtb). MDSCs readily phagocytosed Mtb, released proinflammatory (IL-6, IL-1M-NM-1) and immunomodulatory (IL-10) cytokines while...
ORGANISM(S): Mus musculus 
2014-12-21 | E-GEOD-57124 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of a clinical phase Ia Mycobacterium bovis BCG vaccination study (sex and age matched European (Caucasian) males, 25-35 years, performed in Germany)
Global transcriptome analyses provide an excellent basis for the identification and definition of biomarkers with high relevance in infection processes, therapeutic intervention and protective immunity. The measurement applies three different state of the art transcriptomic technologies for global e...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-51059 | biostudies-arrayexpress
TranscriptomicsGene expression in M. tuberculosis and M. africanum infected tuberculosis patients prior to and following treatment
Differential gene expression in M. tuberculosis and M. africanum patients under TB treatment Gene expression analysis of whole blood RNA from tuberculosis patients prior to and following treatment
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-62147 | biostudies-arrayexpress
UnknownIVIG regulates the survival of human but not mouse neutrophils.
Not available
S-EPMC5430961 | biostudies-literature
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