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UnknownDiscovery and validation of candidate smoltification gene expression biomarkers across multiple species and ecotypes of Pacific salmonids.
Early marine survival of juvenile salmon is intimately associated with their physiological condition during smoltification and ocean entry. Smoltification (parr-smolt transformation) is a developmental process that allows salmon to acquire seawater tolerance in preparation for marine living. Traditi...
S-EPMC6788492 | biostudies-literature
TranscriptomicsIdentification of RNase L-dependent, 3M-bM-^@M-2-end-modified, viral small RNAs in Sindbis virus-infected mammalian cells
Small RNAs play a critical role in host-pathogen interaction. In insects, for instance, small RNA-mediated silencing or RNA interference (RNAi) represents the main antiviral defense system. However, the antiviral role of RNAi has not been clearly proven in higher vertebrates. On the contrary, it is ...
ORGANISM(S): Chlorocebus aethiops 
2013-11-19 | E-GEOD-48831 | biostudies-arrayexpress
UnknownClustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.

Background

Deep immune receptor sequencing, RepSeq, provides unprecedented opportunities for identifying and studying condition-associated T-cell clonotypes, represented by T-cell receptor (TCR) CDR3 sequences. However, due to the immense diversity of the immune repertoire, identification of...
S-EPMC7993519 | biostudies-literature
UnknownCoeliac disease re-screening among once seronegative at-risk relatives: A long-term follow-up study.

Background

Serological screening of the relatives of coeliac disease patients is widely endorsed. However, the need for and the optimal timing of possible re-testing of once seronegative at-risk individuals for coeliac disease remain unclear.

Objective

We investigated this issue by in...
S-EPMC9278577 | biostudies-literature
UnknownSignificance of low ferritin without anaemia in screen-detected, adult coeliac disease patients.

Background

Low ferritin without anaemia has been linked to adverse health effects.

Objectives

To investigate the prevalence and clinical significance of low ferritin in screen-detected coeliac disease.

Methods

Seventy-six screen-detected coeliac disease patients were enrolled i...
S-EPMC9805163 | biostudies-literature
UnknownLong-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood.

Background

The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure.

Objective

To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screenin...
S-EPMC6137595 | biostudies-literature
UnknownDaily Life Restrictions are Common and Associated with Health Concerns and Dietary Challenges in Adult Celiac Disease Patients Diagnosed in Childhood.
The prevalence and associated factors of daily life restrictions due to a gluten-free diet in adult celiac disease patients diagnosed in childhood are poorly known. We investigated these issues by collecting the medical data of 955 pediatric patients and sending questionnaires evaluating various hea...
S-EPMC6723871 | biostudies-literature
UnknownBulb biopsies for diagnosing celiac disease in children: A prospective multicenter study using quantitative histomorphometry.

Objectives

Duodenal bulb specimens are recommended for the diagnostic evaluation of celiac disease (CeD). However, it remains unclear if their quality and histomorphometry measures are comparable to samples obtained from the distal duodenum. We investigated this issue, as well as the diagnos...
S-EPMC12780468 | biostudies-literature
UnknownCoexisting Type 1 Diabetes, Persistent Symptoms, and Financial Issues Associate With Poorer Adherence to a Gluten-Free Diet in Celiac Disease After Transition From Pediatrics to Adult Care.

Purpose

We evaluated adherence to a gluten-free diet and associated factors in adult celiac disease patients diagnosed in childhood.

Methods

Comprehensive medical data on 955 pediatric celiac disease patients was collected and study questionnaires sent to 559 who were now adults. All ...
S-EPMC9200750 | biostudies-literature
UnknownDifferences Between Familial and Sporadic Celiac Disease.

Background

It is not known if genetic background, characteristics at diagnosis, physical and psychological well-being, and adherence to a gluten-free diet are comparable between patients with familial or sporadic celiac disease. These issues were investigated in a follow-up study.

Methods...

S-EPMC8163668 | biostudies-literature
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