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ProteomicsDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradationDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
E3 ubiquitin ligases of the Cullin RING Ligase (CRL) family assemble into multiprotein complexes to diversify substrate adaptors and ensure selectivity in substrate engagement for degradation. Here we show a novel mechanism whereby mutations in substrate adaptors can drive neo-substrate degradation ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031683 | Pride
Medulloblastoma Kbtbd4 Ubiquitin Corest Epigenetic remodelling 
GenomicsUM171 effect in AML1 cells in KBTBD4 null context
UM171 effect in AML1 cells in KBTBD4 null context
PRJNA660784 | ENA
UnknownConverging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.
Not available
S-EPMC11882451 | biostudies-literature
GenomicsDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
PRJNA809413 | ENA
TranscriptomicsUM171 effect in AML1 cells in KBTBD4 null context
UM171 and TCP1 effect in AML1 cellsengeneered to express low levels of KBTBD4 and/or RCOR1
ORGANISM(S): Homo sapiens 
2021-03-09 | GSE157296 | GEO
UnknownDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.
Not available
S-EPMC9525703 | biostudies-literature
UnknownStructural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment.
Not available
S-EPMC11965401 | biostudies-literature
TranscriptomicsDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
E3 ubiquitin ligases of the Cullin RING Ligase (CRL) family assemble into multiprotein complexes to diversify substrate adaptors and ensure selectivity in substrate engagement for degradation. Here we show a novel mechanism whereby mutations in substrate adaptors can drive neo-substrate degradation ...
ORGANISM(S): Homo sapiens 
2022-03-30 | GSE197240 | GEO
ProteomicsAsymmetric Engagement of Dimeric CRL3/KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes
UM171 is a potent agonist of ex vivo human hematopoietic stem cell (HSC) self-renewal1. By co-opting KBTBD4, a substrate receptor of the CULLIN3-RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the degradation of the LSD1-CoREST corepressor complex, thereby limiting HSC attrition2,3. However,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-18 | MSV000096456 | MassIVE
GenomicsA novel CULLIN3-KBTBD4 ligase complex controls the epigenetic marks that mediate human hematopoietic stem cell self-renewal
A novel CULLIN3-KBTBD4 ligase complex controls the epigenetic marks that mediate human hematopoietic stem cell self-renewal
PRJNA660778 | ENA
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